Cholecystectomy has been made with benign conditions usually. The aim of this study is to compare the macroscopic evaluations of the cholecystectomy specimens with it's histopathological examinations.

Cholecystectomy is one of the most frequently performed surgery in the world and often made with benign conditions. Routinely cholecystectomy specimens sent for histopathologic examination. The histopathologic examination of the cholecystectomy specimens are benign in most of the cases and the incidental malignancy of the gallbladder is 2-2.9% in the literature. The histopathologic evaluations of the gallbladder come with additional workload for pathology and surgery departments. Also there is additional cost for the patients. Because of that the idea of selective histopathologic examination has been raised.

Inclusion Criteria:

• Subject has cholelithiasis

Exclusion Criteria:

• Subject has acute cholecystitis
• Subject has perforated gallbladder
• Subject has malignancy
• Subject has polyps in the gallbladder
• Subject has increasing wall thickness of the gallbladder
• Subject has malignancy in the preoperative ultrasonography in the gallbladder
• Subject has pregnancy

1000 patients who is operated with non inflamated cholelithiasis will be included to this study.

Because the time period of this study is very short