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The investigators believe that there is an association between H. pylori infection and nutritional status and between H. pylori infection and cognitive development. The current study will examine this association in Israeli children, aged 6-12 years.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| H.pylori positive children | Healthy children, 6-12 years old, will undergo screening for H. pylori infection by measuring anti-H. pylori and CagA IgG antibodies in the serum. The status of H. pylori infection will be confirmed using breath test (UBT). Children will be classified as i) H. pylori negative, if they test negative on UBT ii) H. pylori positive- CagA negative, if they test positive on UBT, but lack serum CagA IgG antibodies iii) H. pylori positive- CagA positive, if they are positive for H. pylori on UBT and CagA IgG antibodies. | ||
| H.Pylori negative children | Healthy children, 6-12 years old, will undergo screening for H. pylori infection by measuring anti-H. pylori and CagA IgG antibodies in the serum. The status of H. pylori infection will be confirmed using breath test (UBT). Children will be classified as i) H. pylori negative, if they test negative on UBT ii) H. pylori positive- CagA negative, if they test positive on UBT, but lack serum CagA IgG antibodies iii) H. pylori positive- CagA positive, if they are positive for H. pylori on UBT and CagA IgG antibodies. |
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| Measure | Description | Time Frame |
|---|---|---|
| Changes in means of differences in height | The means of the differences in height for age Z score between baseline and follow-up visits | Two years |
| Changes in means of differences in weight | The means of the differences in weight for age Z score between baseline and follow-up visits | Two years |
| Changes in means of differences in body mass index | The means of the differences in body mass index for age Z score between baseline and follow-up visits | Two years |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Iron Biomarkers | The means of the differences in iron biomarkers (hemoglobin, ferritin, iron) between baseline and follow-up visits | Two years |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Intelligence quotient (IQ) scores | Changes in full-Scale IQ scores and-sub-scores on WISC test between baseline and 24-months follow-up visit: will be defined as the means of the differences of these scores. | Two years |
Inclusion Criteria:
Exclusion Criteria:
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Healthy children aged 6-12 years residing in the catchment areas of primary care clinics in the Hadera sub-district of Israel.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Amit Hochberg, MD | Contact | 972-4-6304320 | amit.hochberg@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hillel Yaffe Medical Center | Hadera | 38100 | Israel |
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| ID | Term |
|---|---|
| D018798 | Anemia, Iron-Deficiency |
| ID | Term |
|---|---|
| D000747 | Anemia, Hypochromic |
| D000740 | Anemia |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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Blood samples will be taken for analysis and will be retained for later investigation.
| D000090463 |
| Iron Deficiencies |
| D019189 | Iron Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |