Primary purpose:

Complications and rehospitalizations after transperineal prostate biopsy MRI-guided are reduced than transrectal prostate biopsies.

Secondary purposes:

• Patients tolerance after transperineal prostate biopsy MRI-guided is better than after transrectal prostate biopsies.
• Core of transperineal prostate biopsies are better than core of transrectal prostate biopsies
• Study of correlation between radiologic images and anatomopathologic result
• Description of needle track during the procedure
• Description of real time template saturation prostate biopsy
• Comparison of transperineal prostate biopsy relevance according to EBM
• Comparison of 1.5T MRI and 3T MRI for prostate cancer detection

Inclusion criteria:

• Men
• 40 to 80 years' old
• Affiliation to French social health system
• Signed consent
• Prostate cancer suspicion based on prostate specific antigen (PSA) or digital rectal exam WITH abnormal MRI (Prostate Imaging Reporting and Data System score 3) AND negative transrectal prostate biopsies
• Patient treated by active surveillance for a low risk prostate cancer (T1c or T2a, Gleason = 6, PSA < 10)

Exclusion criteria:

• Gleason > 6 prostate cancer
• Metastatic prostate cancer
• Contraindication to MRI
• Contraindication to general anesthesia
• Non-reversible hemostasis trouble
• Inability to give consent