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| Name | Class |
|---|---|
| ONIRIS | INDUSTRY |
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The investigators wish to highlight, in a Case-Control design, if there is an increased concentration of BFRs in omental adipose tissue of cases ( women with severe endometriosis with surgical indication ) versus bioaccumulation recorded in a control cohort ( women recruited in obstetrics and gynecology or visceral surgery showing no sign of endometriosis ) . Pairing will be operate on Age (+/- 5 years compared to the case ) , BMI ( BMI 5 Classes described by the HAS) and previous breastfeeding experience (yes / no , opposite the release expected bioaccumulate contaminants in breast adipose tissue , when the lactation ) .
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Case Group | 38 women with severe and deep endometriosis, aged 18 to 45 years old and hospitalized at Nantes University Hospital for surgical indication of endometriosis lesions ablation. | ||
| Control Group | 38 women aged 18 to 45 years old without suggestive signs of endometriosis |
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| Measure | Description | Time Frame |
|---|---|---|
| Concentrations of brominated flame retardant (BFR) in adipose tissue and serum | baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Concentrations of dioxins in adipose tissue and serum | baseline | |
| Concentrations of polychlorinated biphenyls (PCBs), | baseline | |
| Concentrations of organochlorine pesticides (OCPs) in adipose tissue and serum |
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Inclusion criterion for de cases :
Inclusion criterion for the controls :
Exclusion criterion for the cases :
Exclusion criterion for controls :
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38 women with severe and deep endometriosis, aged 18 to 45 years old and hospitalized at Nantes University Hospital for surgical indication of endometriosis lesions ablation.
And 38 women aged 18 to 45 years old without suggestive signs of endometriosis
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| Name | Affiliation | Role |
|---|---|---|
| Stephane PLOTEAU, Dr | Nantes University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nantes University Hospital | Nantes | 44093 | France |
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| ID | Term |
|---|---|
| D004715 | Endometriosis |
| ID | Term |
|---|---|
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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omental adipose tissue
| baseline |
| D000091662 | Genital Diseases |