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| Name | Class |
|---|---|
| Ullevaal University Hospital | OTHER |
| Vestre Viken Hospital Trust | OTHER |
| Haukeland University Hospital | OTHER |
| University Hospital of North Norway |
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A prospective observational multicenter study aiming to describe incidence, and identify predictors for development of poststroke dementia (PSD) and mild cognitive impairment (MCI) after stroke
About 15000 Norwegians suffer a stroke every year and 2/3 will be more or less disabled. In addition to motor impairments and comorbidities, disability after stroke is often related to post stroke dementia (PSD) or mild neurocognitive disorder (NCD). However, these problems are hardly addressed in stroke or dementia research and frequently ignored in clinical practise. In the Nor-COAST study an interdisciplinary research group will collaborate to establish a research platform across all Norwegian Health Authorities. The overall aim of the study is to improve competence on PSD and NCD in order to improve individual health outcomes following a stroke. The specific objectives are to determine the incidence of PSD and NCD and the consequences on function and use of health care services and to enhance the early detection of PSD and NCD by identifying a set of risk factors, ranging from genetics to physical activity. The incidence and impact of PSD and NCD on function and use of health care services, medication and life-style changes are important when planning future health care services. Tools identifying patients at risk might improve diagnostic work up and together with knowledge on pathogenic aspects it will contribute to future treatment and prevention of PSD and NCD.
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| Measure | Description | Time Frame |
|---|---|---|
| Score on the Montreal cognitive assessment (MOCA) | Performance based test | 18 months |
| Measure | Description | Time Frame |
|---|---|---|
| Score on the Montreal cognitive assessment (MOCA) | Performance based test | 3 months |
| Time spent in upright position | measured by bodyworn sensors |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with acute stroke
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| Name | Affiliation | Role |
|---|---|---|
| Lars Jacob Stovner, md prof | Norwegian University of Science and Technology | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Norwegian University of Science and Technology | Trondheim | 7006 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30477436 | Background | Thingstad P, Askim T, Beyer MK, Brathen G, Ellekjaer H, Ihle-Hansen H, Knapskog AB, Lydersen S, Munthe-Kaas R, Naess H, Pendlebury ST, Seljeseth YM, Saltvedt I. The Norwegian Cognitive impairment after stroke study (Nor-COAST): study protocol of a multicentre, prospective cohort study. BMC Neurol. 2018 Nov 26;18(1):193. doi: 10.1186/s12883-018-1198-x. | |
| 33663430 |
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| ID | Term |
|---|---|
| D003704 | Dementia |
| D060825 | Cognitive Dysfunction |
| D020521 | Stroke |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D019965 | Neurocognitive Disorders |
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| OTHER |
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blood samples
| 3 months |
| Time spent in upright position | measured by bodyworn sensors | 18 months |
| Brain Imaging | MRI | 18 months |
| Score on Short Physical Performance Battery (sppb) | Performance based test for mobility and lower extremity function | 3 months |
| Score on Short Physical Performance Battery (sppb) | Physical function by performance based tests | 18 months |
| Selfreported habits concerning smoking, alcohol, diet and medication using standardised questionnaires | 3 months |
| Selfreported habits concerning smoking, alcohol, diet and medication using standardised questionnaires | 18 months |
| Waehler IS, Saltvedt I, Lydersen S, Fure B, Askim T, Einstad MS, Thingstad P. Association between in-hospital frailty and health-related quality of life after stroke: the Nor-COAST study. BMC Neurol. 2021 Mar 4;21(1):100. doi: 10.1186/s12883-021-02128-5. |
| 41315409 | Derived | Sandvig HV, Saltvedt I, Edwin TH, Aam S, Alme KN, Eldholm RS, Lydersen S, Mollnes TE, Munthe-Kaas R, Ueland PM, Ulvik A, Wethal T, Knapskog AB. Associations between systemic inflammation and cognitive trajectories post-stroke. Sci Rep. 2025 Nov 28;15(1):42791. doi: 10.1038/s41598-025-27119-1. |
| 38428649 | Derived | Sandvig HV, Aam S, Alme KN, Lydersen S, Magne Ueland P, Ulvik A, Wethal T, Saltvedt I, Knapskog AB. Neopterin, kynurenine metabolites, and indexes related to vitamin B6 are associated with post-stroke cognitive impairment: The Nor-COAST study. Brain Behav Immun. 2024 May;118:167-177. doi: 10.1016/j.bbi.2024.02.030. Epub 2024 Feb 28. |
| 38242298 | Derived | Luzum G, Thrane G, Aam S, Eldholm RS, Grambaite R, Munthe-Kaas R, Thingstad P, Saltvedt I, Askim T. A Machine Learning Approach to Predict Post-stroke Fatigue. The Nor-COAST study. Arch Phys Med Rehabil. 2024 May;105(5):921-929. doi: 10.1016/j.apmr.2023.12.005. Epub 2024 Jan 17. |
| 38195396 | Derived | Navickaite E, Saltvedt I, Lydersen S, Munthe-Kaas R, Ihle-Hansen H, Grambaite R, Aam S. Diagnostic accuracy of the Clock Drawing Test in screening for early post-stroke neurocognitive disorder: the Nor-COAST study. BMC Neurol. 2024 Jan 9;24(1):22. doi: 10.1186/s12883-023-03523-w. |
| 37440440 | Derived | Luzum G, Gunnes M, Lydersen S, Saltvedt I, Tan X, Thingstad P, Thrane G, Askim T. Physical Activity Behavior and Its Association With Global Cognitive Function Three Months After Stroke: The Nor-COAST Studydagger. Phys Ther. 2023 Dec 6;103(12):pzad092. doi: 10.1093/ptj/pzad092. |
| 37026459 | Derived | Sandvig HV, Aam S, Alme KN, Askim T, Beyer MK, Ellekjaer H, Ihle-Hansen H, Lydersen S, Mollnes TE, Munthe-Kaas R, Naess H, Saltvedt I, Seljeseth YM, Thingstad P, Wethal T, Knapskog AB. Plasma Inflammatory Biomarkers Are Associated With Poststroke Cognitive Impairment: The Nor-COAST Study. Stroke. 2023 May;54(5):1303-1311. doi: 10.1161/STROKEAHA.122.041965. Epub 2023 Apr 7. |
| 35459718 | Derived | Gynnild MN, Hageman SHJ, Spigset O, Lydersen S, Saltvedt I, Dorresteijn JAN, Visseren FLJ, Ellekjaer H. Use of lipid-lowering therapy after ischaemic stroke and expected benefit from intensification of treatment. Open Heart. 2022 Apr;9(1):e001972. doi: 10.1136/openhrt-2022-001972. |
| 35183106 | Derived | Munthe-Kaas R, Aam S, Saltvedt I, Wyller TB, Pendlebury ST, Lydersen S, Hagberg G, Schellhorn T, Rostoft S, Ihle-Hansen H. Is Frailty Index a better predictor than pre-stroke modified Rankin Scale for neurocognitive outcomes 3-months post-stroke? BMC Geriatr. 2022 Feb 19;22(1):139. doi: 10.1186/s12877-022-02840-y. |
| 35181266 | Derived | Einstad MS, Thingstad P, Lydersen S, Gunnes M, Saltvedt I, Askim T. Physical Performance and Cognition as Predictors of Instrumental Activities of Daily Living After Stroke: A Prospective Multicenter Cohort Study. Arch Phys Med Rehabil. 2022 Jul;103(7):1320-1326. doi: 10.1016/j.apmr.2022.01.153. Epub 2022 Feb 16. |
| 34879833 | Derived | Alme KN, Ulvik A, Askim T, Assmus J, Mollnes TE, Naik M, Naess H, Saltvedt I, Ueland PM, Knapskog AB. Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke. BMC Neurol. 2021 Dec 8;21(1):476. doi: 10.1186/s12883-021-02498-w. |
| 34399717 | Derived | Alme KN, Askim T, Assmus J, Mollnes TE, Naik M, Naess H, Saltvedt I, Ueland PM, Ulvik A, Knapskog AB. Investigating novel biomarkers of immune activation and modulation in the context of sedentary behaviour: a multicentre prospective ischemic stroke cohort study. BMC Neurol. 2021 Aug 16;21(1):318. doi: 10.1186/s12883-021-02343-0. |
| 34126944 | Derived | Schellhorn T, Zucknick M, Askim T, Munthe-Kaas R, Ihle-Hansen H, Seljeseth YM, Knapskog AB, Naess H, Ellekjaer H, Thingstad P, Wyller TB, Saltvedt I, Beyer MK. Pre-stroke cognitive impairment is associated with vascular imaging pathology: a prospective observational study. BMC Geriatr. 2021 Jun 14;21(1):362. doi: 10.1186/s12877-021-02327-2. |
| 33632149 | Derived | Schellhorn T, Aamodt EB, Lydersen S, Aam S, Wyller TB, Saltvedt I, Beyer MK. Clinically accessible neuroimaging predictors of post-stroke neurocognitive disorder: a prospective observational study. BMC Neurol. 2021 Feb 25;21(1):89. doi: 10.1186/s12883-021-02117-8. |
| 33546620 | Derived | Einstad MS, Saltvedt I, Lydersen S, Ursin MH, Munthe-Kaas R, Ihle-Hansen H, Knapskog AB, Askim T, Beyer MK, Naess H, Seljeseth YM, Ellekjaer H, Thingstad P. Associations between post-stroke motor and cognitive function: a cross-sectional study. BMC Geriatr. 2021 Feb 5;21(1):103. doi: 10.1186/s12877-021-02055-7. |
| 33250039 | Derived | Munthe-Kaas R, Aam S, Saltvedt I, Wyller TB, Pendlebury ST, Lydersen S, Ihle-Hansen H. Test Accuracy of the Montreal Cognitive Assessment in Screening for Early Poststroke Neurocognitive Disorder: The Nor-COAST Study. Stroke. 2021 Jan;52(1):317-320. doi: 10.1161/STROKEAHA.120.031030. Epub 2020 Nov 30. |
| 33243789 | Derived | Alme KN, Knapskog AB, Naess H, Naik M, Beyer M, Ellekjaer H, English C, Hansen HI, Kummeneje CS, Munthe-Kaas R, Saltvedt I, Seljeseth Y, Tan X, Thingstad P, Askim T. Is long-bout sedentary behaviour associated with long-term glucose levels 3 months after acute ischaemic stroke? A prospective observational cohort study. BMJ Open. 2020 Nov 26;10(11):e037475. doi: 10.1136/bmjopen-2020-037475. |
| 32743852 | Derived | Gynnild MN, Aakeroy R, Spigset O, Askim T, Beyer MK, Ihle-Hansen H, Munthe-Kaas R, Knapskog AB, Lydersen S, Naess H, Rosstad TG, Seljeseth YM, Thingstad P, Saltvedt I, Ellekjaer H. Vascular risk factor control and adherence to secondary preventive medication after ischaemic stroke. J Intern Med. 2021 Mar;289(3):355-368. doi: 10.1111/joim.13161. Epub 2020 Aug 19. |
| D001523 | Mental Disorders |
| D003072 | Cognition Disorders |
| D002561 | Cerebrovascular Disorders |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |