Study of NGM282 in Subjects With Functional Constipation and Healthy Individuals

Study of the Pharmacodynamics of NGM282 on Colonic Transit, Bile Acid Homeostasis, and Fecal Fat in Subjects With Functional Constipation and Healthy Individuals

The purpose of this study is to determine the effect of NGM282 on colonic transit, bile acid homeostasis, and fecal fat in subjects with functional constipation and healthy individuals.

Inclusion Criteria:

• Functional constipation confirmed by modified Rome III criteria or Healthy Volunteer

Exclusion Criteria:

• Structural or metabolic diseases/conditions that affect the GI system
• Diagnosis of dyspepsia, IBS, or significant gastrointestinal symptoms