Effect of Dexmedetomidine on Ischemia-Reperfusion Injury in Lower Extremity Operations

Effect of Dexmedetomidine on Ischemia-Reperfusion Injury in Unilateral Total Knee Replacement - a Randomized, Controlled Trial

Ischemia reperfusion injury causes the release of free oxygen radicals. The selective alpha2-receptor agonist, dexmedetomidine, has an inhibitory effect on inflammatory responses during ischemic injury. The aim of this study is to evaluate the effect of dexmedetomidine on inflammatory responses during ischemia-reperfusion injury in skeletal muscle.

Inclusion Criteria:

• American Society Anesthesiologists classification I-III

Exclusion Criteria:

• use of antioxidants clinically significant cardiovascular, renal, or hepatic diseases heart block greater than the first degree