The Effects of Anti-infective Central Venous Catheter on Catheter-related Infection in Critically Patients

The Effects of Anti-infective Central Venous Catheter(CVC) on Catheter-related Bloodstream Infection(CRBSI) in Critical Care Patients: a Multiple-center, Randomized, Control Study

The purpose of this study is to investigate the effect of anti-infective central venous catheter(Certofix®Protect) on reducing catheter-related bloodstream infection in critically ill patients in China, and the relationship between catheter-related bloodstream infection and catheter-related thrombosis.

Inclusion Criteria:

• adult patients in intensive care unit (ICU)（age ≥ 18 years）
• needs double lumen CVC more than 5 days
• Signed informed consent

Exclusion Criteria:

• thrombosis in target and/or contralateral vein
• pregnancy or lactating women
• unlikely to survive for more than 1 month
• bad prognosis
• suspected catheter-related infection
• replacement CVC in original site through guide wire
• severe burn
• situation that is not suitable for CVC, including allergic to CVC material, thrombosis in target vein, infection of puncture site, coagulation disorder, abnormal anatomy
• already in this study
• participated in other studies within 3 months