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The investigators research the early improvement of fluid retention and mid-term prognosis through the administration of tolvaptan for the patient with tricuspid regurgitation and right heart failure after left heart valves replacement.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| trial group(tolvaptan group) | Active Comparator | trial group (tolvaptan 15mg/d po(10 days) + torasemide 20mg/d iv,n=20) |
|
| control group | Placebo Comparator | control group(placebo 15mg/d po(10 days) +torasemide 20mg/d iv,n=20) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tolvaptan+torasemide | Drug | tolvaptan 15mg/d po(10 days) + torasemide 20mg/d iv |
|
| Measure | Description | Time Frame |
|---|---|---|
| The change of all the subjects'liquid intake and output volume change after a period(10 days) of treatment | 2015.01-2017.12 |
| Measure | Description | Time Frame |
|---|---|---|
| A cumulative urine volume for 72 hours (all subjects) | 2015.01-2017.12 | |
| Echocardiography results VS the baseline results(all subjects) | 2015.01-2017.12 | |
| Change of right heart failure signs(all subjects) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Fang Yuan | Shanghai Chest Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| FangYuan | Shanghai | Shanghai Municipality | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30255476 | Derived | Yuan F, Wu Z, Jiang L, Zhou J, Xu L, Liu H, Ma L, Zhai Z, Zhang J. Short-Term Effects of Tolvaptan in Tricuspid Insufficiency Combined with Left Heart Valve Replacement-Caused Volume-Overload Patients: Results of a Prospective Pilot Study. Am J Cardiovasc Drugs. 2019 Apr;19(2):211-218. doi: 10.1007/s40256-018-0304-1. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Jun 8, 2017 | |
| Reset | Oct 26, 2017 |
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| placebo+torasemide | Drug | placebo 15mg/d po(10 days) +torasemide 20mg/d iv |
|
| 2015.01-2017.12 |
| Onset of cardiovascular event (all subjects) | 2015.01-2017.12 |
| Onset of serious adverse event(all subjects) | 2015.01-2017.12 |
| other adverse events(all subjects) | 2015.01-2017.12 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jun 8, 2017 | Oct 26, 2017 |
| ID | Term |
|---|---|
| D014262 | Tricuspid Valve Insufficiency |
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D006349 | Heart Valve Diseases |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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