Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| KSWEET-02 | Other Identifier | Korean South West East Gastric Surgery Group |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Chonnam National University Hospital | OTHER |
| Dong-A University Hospital | OTHER |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Many features of the metabolic syndrome are associated with insulin resistance. And, metabolic syndrome and insulin resistance are related to visceral obesity. Therefore, the investigators hypothesized that visceral fat removal (omentectomy) can make favorable results for the insulin resistance and metabolic syndrome. As the omentectomy is optional procedure during a surgery for early gastric cancer, the investigators will divide patients randomly into two groups, total omentectomy group and omentum preserving group.
The investigators will compare the change of insulin resistance (HOMA-IR) and improvement of metabolic syndrome between total omentectomy and omentum preserving group.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Omentum preserving | Active Comparator | Omentum preserving: The minimum volume of omentum (within 3cm from gastroepiploic vessel) will be removed. |
|
| Total omentectomy | Experimental | Total omentectomy: Whole omentum will be removed. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Omentum preserving | Procedure | The minimum volume of omentum (within 3cm from gastroepiploic vessel) will be removed during gastrectomy with lymph node dissection. |
|
| Measure | Description | Time Frame |
|---|---|---|
| HOMA-IR change | HOMA-IR change after operation | pre-operative and post-operative 12months |
| Measure | Description | Time Frame |
|---|---|---|
| prevalence of metabolic syndrome | check the presence of metabolic syndrome | pre-operative and post-operative 12months |
| Complication | short-term any complication related to surgery |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Seung Wan Ryu, M.D., Ph.D. | Contact | 82-53-250-7322 | gsman@dsmc.or.kr |
| Name | Affiliation | Role |
|---|---|---|
| Seung Wan Ryu, M.D., Ph.D. | Korean South West East Gastric Surgery Group | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chonnam National University Hwasun Hospital | Recruiting | Hwasun | Jeollanam-do | 519-809 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24409070 | Background | An JY, Kim YM, Yun MA, Jeon BH, Noh SH. Improvement of type 2 diabetes mellitus after gastric cancer surgery: short-term outcome analysis after gastrectomy. World J Gastroenterol. 2013 Dec 28;19(48):9410-7. doi: 10.3748/wjg.v19.i48.9410. | |
| 23404948 | Background | Lima MM, Pareja JC, Alegre SM, Geloneze SR, Kahn SE, Astiarraga BD, Chaim EA, Baracat J, Geloneze B. Visceral fat resection in humans: effect on insulin sensitivity, beta-cell function, adipokines, and inflammatory markers. Obesity (Silver Spring). 2013 Mar;21(3):E182-9. doi: 10.1002/oby.20030. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| D013274 | Stomach Neoplasms |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Total omentectomy | Procedure | Whole omentum will be removed during gastrectomy with lymph node dissection. |
|
| within 30days |
| HOMA-IR change according to anastomosis type | comparison between Billoth-II and Roux-en-Y | pre-operative and post-operative 12months |
| Dong-A University Hospital | Recruiting | Busan | 602-715 | South Korea |
|
| Keimyung University Dongsan Medical Center | Recruiting | Daegu | 700-712 | South Korea |
|
| 19214178 | Background | Lottati M, Kolka CM, Stefanovski D, Kirkman EL, Bergman RN. Greater omentectomy improves insulin sensitivity in nonobese dogs. Obesity (Silver Spring). 2009 Apr;17(4):674-80. doi: 10.1038/oby.2008.642. Epub 2009 Feb 12. |
| 23526069 | Background | Sdralis E, Argentou M, Mead N, Kehagias I, Alexandridis T, Kalfarentzos F. A prospective randomized study comparing patients with morbid obesity submitted to sleeve gastrectomy with or without omentectomy. Obes Surg. 2013 Jul;23(7):965-71. doi: 10.1007/s11695-013-0925-z. |
| 23303913 | Background | Tchernof A, Despres JP. Pathophysiology of human visceral obesity: an update. Physiol Rev. 2013 Jan;93(1):359-404. doi: 10.1152/physrev.00033.2011. |
| 11850750 | Background | Thorne A, Lonnqvist F, Apelman J, Hellers G, Arner P. A pilot study of long-term effects of a novel obesity treatment: omentectomy in connection with adjustable gastric banding. Int J Obes Relat Metab Disord. 2002 Feb;26(2):193-9. doi: 10.1038/sj.ijo.0801871. |
| 20587720 | Background | Herrera MF, Pantoja JP, Velazquez-Fernandez D, Cabiedes J, Aguilar-Salinas C, Garcia-Garcia E, Rivas A, Villeda C, Hernandez-Ramirez DF, Davila A, Zarain A. Potential additional effect of omentectomy on metabolic syndrome, acute-phase reactants, and inflammatory mediators in grade III obese patients undergoing laparoscopic Roux-en-Y gastric bypass: a randomized trial. Diabetes Care. 2010 Jul;33(7):1413-8. doi: 10.2337/dc09-1833. |
| D009750 |
| Nutritional and Metabolic Diseases |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D013272 | Stomach Diseases |