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The primary purpose of this study is to examine the health effects of mainstream and secondhand hookah (i.e. water pipe) smoke on pulmonary and cardiovascular functions as well as serum levels of inflammatory biomarkers. Investigators would like to demonstrate that inhalation of both mainstream and secondhand smoke generated by hookah produces adverse pulmonary and cardiovascular effects and alterations in serum levels of inflammatory biomarkers.
A total of 20 participants are going to be enrolled in this study; 10 participants smoke hookah and 10 participants are exposed to second hand hookah smoke for 2 hours in NYC hookah bars. Subjects in the control group will also be paired as they were for the hookah bar visit but will visit a control location, where they will be asked to consume a similar amount of food and drink at a wine bar. Pulmonary function, cardiovascular changes, and blood and urine markers of inflammatory mediators before, immediately after and 24 hours after the participants' visits to hookah bars and wine bars will be examined. Air quality monitoring will also be performed at the hookah bar and at the control location. Physiological changes will be assessed by measuring pulmonary function, blood pressure, heart rate, and blood oxygenation status. To determine the extent of tobacco exposure and associated inflammatory changes from secondhand hookah smoke, investigators will measure blood inflammatory biomarkers, oxidative stress, gene expression, tobacco-related carcinogenic metabolites, and exhaled carbon dioxide levels.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hookah Smoking Group | Active Comparator | 10 participants will smoke tobacco hookah for 2 hours |
|
| Hookah Secondhand Smoke Group | Active Comparator | 10 individuals will be exposed to secondhand hookah tobacco smoke for 2 hours |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Active smoking of Tobacco Hookah for 2 hours | Other |
| ||
| Exposure to tobacco hookah second hand smoke |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in exhaled carbon dioxide measured by pulmonary function measure using a portable spirometer | subsequently after 2 hours of hookah smoking or smoke exposure and 24 hours after participants' visit hookah and wine bars. | |
| Changes in Heart Rate measured by a portable monitor worn during encounters | subsequently after 2 hours of hookah smoking and 24 hours after participants' visit hookah and wine bars. | |
| Changes in blood oxygenation levels measured by a pulse oximeter | subsequently after 2 hours of hookah smoking and 24 hours after participants' visit hookah and wine bars. | |
| Changes in measure of tobacco-related carcinogenic metabolite cotinine in saliva samples | subsequently after 2 hours of hookah smoking and 24 hours after participants' visit hookah and wine bars. | |
| Changes in measure of blood inflammatory marker endothelin | subsequently after 2 hours of hookah smoking and 24 hours after participants' visit hookah and wine bars. | |
| Changes in measure of blood inflammatory marker IL-10 | subsequently after 2 hours of hookah smoking and 24 hours after participants' visit hookah and wine bars. | |
| Changes in measure of blood inflammatory marker IL-8 | subsequently after 2 hours of hookah smoking and 24 hours after participants' visit hookah and wine bars. | |
| Changes in measure of blood inflammatory marker IL-6 | subsequently after 2 hours of hookah smoking and 24 hours after participants' visit hookah and wine bars. |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Air Quality measured by an aethelometer | 2 hours spent at hookah bar |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Michael Weitzman, MD | NYU Langone Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| New York University School of Medicine | New York | New York | 10016 | United States |
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| D012907 | Smoking |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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| Other |
|
| Visit a win bar | Other | Participants will visit a wine bar for food and/or drinks |
|
| Changes in measure of blood inflammatory marker CRP | subsequently after 2 hours of hookah smoking and 24 hours after participants' visit hookah and wine bars. |
| Changes in measure of blood inflammatory marker IL-1a | subsequently after 2 hours of hookah smoking and 24 hours after participants' visit hookah and wine bars. |
| Changes in measure of blood inflammatory marker IFN-g | subsequently after 2 hours of hookah smoking and 24 hours after participants' visit hookah and wine bars. |
| Changes in measure of blood inflammatory marker TNF-a | subsequently after 2 hours of hookah smoking and 24 hours after participants' visit hookah and wine bars. |
| Changes in measure of blood inflammatory marker GM-CSF | subsequently after 2 hours of hookah smoking and 24 hours after participants' visit hookah and wine bars. |
| Changes in measure of blood inflammatory marker E-selectin | subsequently after 2 hours of hookah smoking and 24 hours after participants' visit hookah and wine bars. |
| Changes in measure of blood inflammatory marker thrombomodulin | subsequently after 2 hours of hookah smoking and 24 hours after participants' visit hookah and wine bars. |
| Changes in measure of blood inflammatory marker vWF | subsequently after 2 hours of hookah smoking and 24 hours after participants' visit hookah and wine bars. |
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |