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The purpose of the current study was to check the physiological improvement of SWT on liver and skin and also the antioxidation in healthy adults.
Background: Si-Wu-Tang (SWT) is a well-known traditional Chinese medicine (TCM) and widely used for treating various gynecological disorders. The purpose of the current study was to check the physiological improvement of SWT on liver and skin and also the antioxidation in healthy adults.
Methods: Sixty healthy voluntary subjects were recruited and assigned into two groups, who drank 125 mL of placebo (n=30) or SWT (n=30) for 6 continuous days per month during the following 6 months and vice versa with one month of washout period in between. During the initial, 3rd, 6th, 10th, and 13th months anthropometric measurements were performed as well as fasting blood samples were drawn for various biochemical assays. Abdominal ultrasonic and skin examination were performed at the initial, 6th and 13th months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Si-Wu-Tang (SWT) | Experimental | Subjects are recommended to drink 125 mL of SWT (n=30) for 6 continuous days per month during the following 6 months and vice versa with one month of washout period in between. |
|
| placebo | Placebo Comparator | Subjects are recommended to drink 125 mL of Placebo (n=30) for 6 continuous days per month during the following 6 months and vice versa with one month of washout period in between. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Si-Wu-Tang (SWT) | Other | The purpose of the current study was to check the physiological improvement of SWT on liver and skin and also the antioxidation in healthy adults. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Total thiobarbituric acid reactive substances (TBARS) | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Glutathione content (GSH) | 6 months | |
| Total antioxidant capacity (TEAC)activities. | 6 months | |
| Superoxide dismutase (SOD) activity |
| Measure | Description | Time Frame |
|---|---|---|
| Skin sebum content | 6 months | |
| Skin hydration | 6 months | |
| Skin surface water loss |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Chin-Kun Wang | Chung Shan Medical University | Study Chair |
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| ID | Term |
|---|---|
| D005831 | Genital Diseases, Female |
| ID | Term |
|---|---|
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
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| ID | Term |
|---|---|
| C403258 | si-wu-tang |
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|
| placebo | Other | The purpose of the current study was to check the physiological improvement of placebo on liver and skin and also the antioxidation in healthy adults. |
|
| 6 months |
| GPx and glutathione reductase (GR) activity | 6 months |
| Catalase | 6 months |
| Glutamic oxaloacetic transaminase (GOT) | 6 months |
| Glutamic pyruvic transaminase (GPT) | 6 months |
| 6 months |
| Skin melanin index | 6 months |
| Skin elasticity | 6 months |