Influenza Vaccine in HIV Study

A Comparison of Immune Responses to the Licensed Trivalent Inactivated Influenza Vaccine in HIV-positive and HIV-negative Subjects

The aims of this study are:

1. to investigate if HIV infection alters the antibody responses to influenza and
2. to assess the ability of licensed influenza vaccine to induce functional non-neutralising antibodies in HIV-infected and HIV-uninfected subjects.

Inclusion Criteria:

• HIV-1 positive by licensed diagnostic test (for HIV-positive group only)
• Planning to receive the seasonal influenza vaccine outside the study
• Provision of written informed consent

Exclusion Criteria:

• Previous allergy to influenza vaccination
• Pregnancy or planning to become pregnant
• Unwilling or unable to provide blood samples