Disruption of Memory Reconsolidating as a Treatment for Panic Disorder

Targeting Fear Memory by Disrupting the Process of Reconsolidating: A New Intervention for Panic Disorder

Animal and human fear conditioning studies have repeatedly shown that administering propranolol before or after retrieval of a previously acquired fear results in an elimination of the fear expression. This approach, known as disruption of fear memory reconsolidation, is a promising new avenue for treating anxiety disorders. The present study aims to test its efficacy in patients with panic disorder.

Inclusion Criteria:

• a primary diagnosis of panic disorder according to DSM-V
• written approval of an independent physician for participation

Exclusion Criteria:

• other relevant treatment for panic disorder at the time of study - e.g., Cognitive Behavioral Therapy (CBT)
• diagnosis of depression
• diagnosis of psychosis
• use of psychotropic medication
• history of pulmonary diseases
• metabolic acidosis
• history of cardiovascular diseases
• heart problems among first-degree relatives
• heart rate (HR) < 60
• blood pressure (BP) < 90-60 or BP > 170-100
• history of black-outs or fainting
• diabetes
• liver or kidney diseases
• hyperactive production of thyroid hormones
• epilepsy
• any medication contra-indicative of the use of propranolol
• pregnancy