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Animal and human fear conditioning studies have repeatedly shown that administering propranolol before or after retrieval of a previously acquired fear results in an elimination of the fear expression. This approach, known as disruption of fear memory reconsolidation, is a promising new avenue for treating anxiety disorders. The present study aims to test its efficacy in patients with panic disorder.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Fear reactivation with propranolol | Experimental |
| |
| Fear reactivation with placebo | Placebo Comparator |
| |
| No fear reactivation with propranolol | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Propranolol | Drug | Intake of propranolol pill (40 milligram) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in the number of participants diagnosed with panic disorder assessed by the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, fourth addition (DSM-IV) Axis I Disorders | Baseline and 3 months | |
| Change in score on the Panic Disorder Severity Scale (PDSS-SR) | Baseline, 7 days, 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Carbon dioxide challenge using a visual analogue scale ranging from 0-100 mm | Participants are asked to rate on a visual analogue scale ranging from 0-100 mm the degree to which they are willing to inhale carbon dioxide again if this were requested. Secondly, participants will indeed be requested to perform the challenge a second time and rate on the visual analogue scale how anxious it made them feel. |
| Measure | Description | Time Frame |
|---|---|---|
| Score on the Anxiety Sensitivity Index (ASI) | Baseline |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Arnold A.P. van Emmerik, PhD | Contact | 0031205258604 | A.A.P.vanEmmerik@uva.nl |
| Name | Affiliation | Role |
|---|---|---|
| Merel Kindt, Prof. dr. | University of Amsterdam | Principal Investigator |
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| ID | Term |
|---|---|
| D016584 | Panic Disorder |
| ID | Term |
|---|---|
| D001008 | Anxiety Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D011433 | Propranolol |
| D002245 | Carbon Dioxide |
| D058868 | Compressed Air |
| ID | Term |
|---|---|
| D050198 | Phenoxypropanolamines |
| D011412 | Propanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
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| Placebo | Drug | Intake of placebo pill (40 milligram) |
|
| Carbon dioxide | Other | Inhalation of 35% carbon dioxide |
|
| Compressed air | Other | Inhalation of air |
|
| 3 months |
| Change in score on the Panic Appraisal Inventory (PAI) | Baseline, 7 days, 3 months, 6 months, 1 year |
| Change in score on the Mobility Inventory (MI) | Baseline, 7 days, 3 months, 6 months, 1 year |
| Change in score on the Body Sensations Questionnaire (BSQ) | Baseline, 7 days, 3 months, 6 months, 1 year |
| Change in score on the Agoraphobic Cognitions Questionnaire (ACQ) | Baseline, 7 days, 3 months, 6 months, 1 year |
| Change in the number of participants diagnosed with panic disorder assessed by the Structured Clinical Interview for DSM-IV Axis I Disorders | Baseline, 6 months, 1 year |
| Change in score on the Panic Disorder Severity Scale (PDSS-SR) | Baseline, 6 months, 1 year |
| D009930 |
| Organic Chemicals |
| D020005 | Propanols |
| D000588 | Amines |
| D009281 | Naphthalenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D011083 | Polycyclic Compounds |
| D017554 | Carbon Compounds, Inorganic |
| D007287 | Inorganic Chemicals |
| D005740 | Gases |
| D010087 | Oxides |
| D017601 | Oxygen Compounds |
| D004864 | Equipment and Supplies |
| D000388 | Air |
| D001272 | Atmosphere |
| D004777 | Environment |
| D055669 | Ecological and Environmental Phenomena |
| D001686 | Biological Phenomena |
| D008685 | Meteorological Concepts |
| D004778 | Environment and Public Health |