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| Name | Class |
|---|---|
| Abbott Nutrition | INDUSTRY |
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The aim of this study is to investigate the acute effects of ingestion of carbohydrates - with different glycemic profiles - on cognitive function among preadolescent children (i.e., 9-10 years).
Regular breakfast consumption is linked to improved cognitive performance in school-aged children. However, the acute benefits of defined nutrient consumption on brain and cognitive health are not well understood, particularly in preadolescent children. One factor that may relate to brain health and learning in children is the contribution of carbohydrates to the digestion rate of a meal (and associated effects on post-prandial glycemia).
The effects of differentially absorbed carbohydrates on brain and cognition are unknown, especially when ingested via a fortified nutritional beverage providing a balanced array of nutrients. The aim of this study is to investigate the acute, transient effect of nutrient supplementation with varied carbohydrate systems in preadolescent children (i.e., 9-10 years).
Participants will be randomized to receive one of three treatment nutritional formulations containing carbohydrates with varying absorption rates along with a non-caloric placebo. Participants will perform a cognitive battery in the fasted condition, shortly after treatment ingestion, and an hour after ingestion. Group differences in performance will be contrasted to assess the effects of different carbohydrate types on children's cognitive function following an overnight fast.
Findings from this study will inform our understanding of the macronutrient profile of breakfast that may potentially improve children's cognitive performance in the morning.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SLOW Carbohydrate | Experimental | Treatment consists of a carbohydrate blend designed to elicit a slow postprandial glycemic response. |
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| MEDIUM Carbohydrate | Experimental | Treatment consists of only one carbohydrate source designed to elicit a medium/moderate postprandial glycemic response. |
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| FAST Carbohydrate | Experimental | Treatment consists of only one carbohydrate source designed to elicit a fast postprandial glycemic response. |
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| Non-Caloric Placebo | Placebo Comparator | Non-caloric placebo consisting of artificial sweeteners |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| SLOW Carbohydrate | Other | Treatment consists of a carbohydrate blend designed to elicit a slow postprandial glycemic response |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in Cognitive Control at 15 minutes Postprandial | Performance will be assessed using the difference in inverse efficiency (during a modified flanker task) between performance at 15 minutes and baseline/fasted (within 2 hours of wake-time) performance. | 15 minutes Postprandial |
| Change in Cognitive Control at 70 minutes Postprandial | Performance will be assessed using the difference in inverse efficiency (during a modified flanker task) between performance at 70 minutes and baseline/fasted (within 2 hours of wake-time). | 70 minutes Postprandial |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Relational Memory at 30 minutes Postprandial | Performance will be assessed using the difference in number of swap errors (during a spatial reconstruction task) by calculating the difference between number of errors performed at baseline/fasted (within 2 hours of wake-time) from number of errors at 30 minutes postprandial. | 30 minutes Postprandial |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Charles Hillman, PhD | University of Illinois at Urbana-Champaign | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Kinesiology and Community Health | Urbana | Illinois | 61801 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31756405 | Derived | Walk AM, Raine LB, Kramer AF, Cohen NJ, Hillman CH, Khan NA. Adiposity is related to neuroelectric indices of motor response preparation in preadolescent children. Int J Psychophysiol. 2020 Jan;147:176-183. doi: 10.1016/j.ijpsycho.2019.10.014. Epub 2019 Nov 19. |
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| MEDIUM Carbohydrate | Other | Treatment consists of only one carbohydrate source designed to elicit a medium/moderate postprandial glycemic response |
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| FAST Carbohydrate | Other | Treatment consists of only one carbohydrate source designed to elicit a fast postprandial glycemic response |
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| Change in Relational Memory at 85 minutes Postprandial | Performance will be assessed using the difference in number of swap errors (during a spatial reconstruction task) by calculating the difference between number of errors performed at baseline/fasted (within 2 hours of wake-time) from number of errors at 85 minutes postprandial. | 85 minutes Postprandial |