[11C]Cimbi-36 Dosimetry

Evaluation of Radiation Dose for [11C]Cimbi-36

The purpose of this study is to determine the dosimetry for the Positron Emission Tomography (PET) tracer [11C]Cimbi-36 in two different Carbon-11 labelling positions. This information will contribute to determining whether [11C]Cimbi-36 can be optimized by changing the C-11 labelling position.

Healthy subjects wil undergo a whole-body Positron Emission Tomography (PET) scan with the Serotonin 2A Receptor (5-HT2A) radioligand [11C]Cimbi-36 or [11C]Cimbi-36-5 to determine the effective radiation dose and radiation dose for selected organs.

Inclusion Criteria:

• 18 years of age
• Signed informed consent

Exclusion Criteria:

• Present or former neurological disease, severe somatic or psychiatric disease, or medication thet can interfere with the test results.
• Pregnancy at the time of the scan
• Breastfeeding
• Alcohol or substance abuse
• Exposure to radiation (>10 millisievert (mSv)) within the last year, or significant exposure at work
• Allergy to any of the substances in the Investigational medicinal product (IMP) formulation