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Prospective observational study of SNIPPV use in preterm infants of less than 32weeks of gestation from January 2012 to December 2015. Previous respiratory status is analyzed as well as respiratory outcomes and possible secondary side effects.
SNIPPV is used to prevent Intubation in Infants in which nCPAP has already failed (Infants that met intubation criteria) and also is used electively for extubation when nCPAP extubation has previously failed or infants with Prolonged mechanical ventilation (more than 15 days) with high respiratory parameters (PMAP > 10 cmH2O and FiO2>35%).
SNIPPV is used to prevent Intubation in Infants in which nCPAP has already failed (Infants that met intubation criteria) and also is used electively for extubation when nCPAP extubation has previously failed or infants with Prolonged mechanical ventilation (more than 15 days) with high respiratory parameters (PMAP > 10 cmH2O and FiO2>35%).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Preterm Infants treated with non-invasive ventilation | Preterm Infants of less than 32 weeks of Gestational age treated with synchronized non-invasive ventilation (SNIPPV) to prevent intubation or extubation failure based in a prospective protocol:
Preterm infants in which nCPAP extubation has previously failed or Prolonged mechanical ventilation (more than 15 days) with high respiratory parameters (PMAP > 10 cmH2O and FiO2>35%). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Preterm Infants treated with non-invasive ventilation. | Other |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Avoid of Invasive Mechanical Ventilation in the next three days. | The rate of infants treated with non-invasisive ventilation that do not need to be intubated in the next three days. | through study completion, an average of 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Time on MV | Days on MV during hospitalitation | through study completion, an average of 1 year |
| Neurological impairment | Intraventricular hemorrhage grade 3 or 4 (papile´s classification) |
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Inclusion Criteria:
Exclusion Criteria: None
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Prospective observational study of SNIPPV use in preterm infants of less than 32 weeks of gestation from January 2012 to December of 2014.
SNIPPV is used for:
nCPAP failure: Preterm infants supported with nCPAP that meet intubation criteria (FiO2>50%; apnea spells more than 4/h or more than 1 that needs PPV) if they are in a stable situation. SAP (systemic arterial pressure)> P10 with preserved respiratory drive (no more than 6 apneas episodes per hour or more than 2 requiring PPI).
Electively For extubation:
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| Name | Affiliation | Role |
|---|---|---|
| Cristina Ramos-Navarro | Gregorio Marañón Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cristina Ramos-Navarro | Madrid | 28033 | Spain |
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| ID | Term |
|---|---|
| D063087 | Noninvasive Ventilation |
| ID | Term |
|---|---|
| D012121 | Respiration, Artificial |
| D058109 | Airway Management |
| D013812 | Therapeutics |
| D012138 | Respiratory Therapy |
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| through study completion, an average of 1 year |
| Rate of patients with air leaks | pulmonary air leak | through study completion, an average of 1 year |