Exercise-induced High-sensitivity Troponin Levels as a Predictor for Obstructive Coronary Artery Disease

Exercise-induced High-sensitivity Troponin Levels as a Predictor for Obstructive Coronary Artery Disease

1. To compare hs-TnT levels after a cardiac stress test in patients with vs. patients without CAD
2. To assess the level of post-exercise hs-TnT predicting CAD (using ROC-analysis)
3. To determine the sensitivity, specificity and accuracy of this exercise-induced hsTopT level in predicting CAD, either alone or in relation to traditional patient-related and exercise test-related metrics

Inclusion Criteria:

1. Patients with suspected CAD, planned for diagnostic coronary angiogram
2. Patients with previous revascularization, suspected of recurrent ischemia

Exclusion Criteria:

1. Congestive cardiomyopathy with LV EF < 35%
2. Renal failure with eGFR < 30 ml/min
3. Known structural or severe valvular heart disease
4. Prior CABG
5. Previous ACS < 6 weeks
6. Known incomplete revascularization after previous PCI
7. Unstable angina or ACS (defined as unstable anginal symptoms + ECG changes or hs-TnT > 0.053 ng/L)