Effect of a Meal Replacement on Weight Loss Obesity Patients With Metabolic Syndrome

Effect of a Meal Replacement on Weight Loss Obesity Patients With Metabolic Syndrome : A Randomized Controlled Trial

The purpose of this study is to determine whether meal replacement, SlimWell ®, is effective in the treatment of obesity patients with metabolic syndrome.

The participants are divided into two groups: intervention group and control group. In the intervention group, the participants receive a meal replacement plus life style modification. In the control group, the participants receive only life style modification.

Sample size calculation is 69 participants per group. Primary outcome is to compare the weight loss between the intervention group and control group.

Inclusion Criteria:

• Body mass index more than or equal to 25 kg/m2
• Patients with metabolic syndrome
• Patients who are on anti-hypertensive drugs, oral hypoglycemic drugs and lipid lowering drugs.

Exclusion Criteria:

• Uncontrolled diabetes patients
• Patients with gastrointestinal abnormalities
• Patients with cardiovascular diseases
• Patients with hematologic disorders
• Patients with Glomerular filtration rate less than 60 ml/min/1.73m2
• Patients with drug or alcohol abuse
• Pregnancy and lactation