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The goal of this project is to find a series novel biomarkers by differential proteomic techniques that can improve the early diagnosis and develop a more efficient therapy to enhance ARDS patient survival rate.
Acute respiratory distress syndrome(ARDS) has a very poor prognosis and high mortality. To improve the early diagnosis of ARDS, there is an urgent need for novel biomarkers of ARDS. The goal of this project is to find a series novel biomarkers by differential proteomic techniques that can improve the early diagnosis and develop a more efficient therapy to enhance ARDS patient survival rate. Clinical data and blood sample were recorded before treatment and after treatment. Acute Physiology And Chronic Health Evaluation III (APACHE III) scores were calculated at enrolment. Studying blood specimens from different period ARDS patients by proteomic analysis. It can provide information on a complex composition of proteins that are differentially expressed, which could be used for discovering high sensitivity and specificity ARDS biomarker.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1: patient at High risk for ARDSp | Severe pneumonia and（PaO2/FIO2）>300mmHg |
| |
| 2: patient at High risk for ARDSexp | Severe sepsis and without ARDS |
| |
| 3: mild ARDS | PaO2/FiO2=201～300 mmHg，and PEEP or CPAP≤5 cm |
| |
| 4: moderate ARDS | PaO2/FIO2=101～200 mmHg，且PEEP≥5 cm H2O |
| |
| 5: severe ARDS | PaO2/FIO2≤100 mmHg，且PEEP≥10 cm H2O |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood samples collection before treatment | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Analysis of serum proteins directly by proteomics analysis to identify new biomarkers of ARDS | baseline | |
| Analysis of serum proteins directly by proteomics analysis to identify new biomarkers of ARDS | 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| APACHE III score | baseline, 1week, 2 weeks | |
| PaO2/FiO2 ratio | baseline, day 3, day 5, 1week, 2 weeks | |
| Mortality or multi-organ failure |
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Inclusion Criteria:
Exclusion Criteria:
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patients at High risk for Extra-pulmonary ARDS and pulmonary ARDS; patients who have ARDS
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Pinhua Pan, MD, Doctor | Contact | +86 13574810968 | pinhuapan668@126.com |
| Name | Affiliation | Role |
|---|---|---|
| Pinhua Pan, MD, Doctor | Xiangya Hospital of Central South University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xiangya Hospital | Changsha | Hunan | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23934723 | Background | Janz DR, Ware LB. Biomarkers of ALI/ARDS: pathogenesis, discovery, and relevance to clinical trials. Semin Respir Crit Care Med. 2013 Aug;34(4):537-48. doi: 10.1055/s-0033-1351124. Epub 2013 Aug 11. | |
| 26174184 | Background | Ware LB, Calfee CS. Biomarkers of ARDS: what's new? Intensive Care Med. 2016 May;42(5):797-799. doi: 10.1007/s00134-015-3973-0. Epub 2015 Jul 15. No abstract available. |
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blood
| Blood samples collection after treatment | Other |
|
| laboratory biomarker proteomic analysis | Other |
|
| 1 month |
| 19858233 | Background | Ware LB, Koyama T, Billheimer DD, Wu W, Bernard GR, Thompson BT, Brower RG, Standiford TJ, Martin TR, Matthay MA; NHLBI ARDS Clinical Trials Network. Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Chest. 2010 Feb;137(2):288-96. doi: 10.1378/chest.09-1484. Epub 2009 Oct 26. |
| ID | Term |
|---|---|
| D012128 | Respiratory Distress Syndrome |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D012120 | Respiration Disorders |
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