Study to Investigate the Absorption, Metabolism and Excretion of [14C] Anlotinib in Patients With Advanced Cancer Patients

A Phase 1, Open-label Study to Investigate the Absorption, Metabolism and Excretion of [14C] Anlotinib in Patients With Advanced Cancer Patients

The purpose of this study is to Investigate the Absorption, Metabolism and Excretion of [14C] Anlotinib in Patients With Advanced Cancer patients.

Inclusion Criteria:

• signed and dated informed consent
• histologically or cytologically confirmed diagnosis of advanced solid tumor (including RCC、NSCLC、STS and CRC)
• failed to the treatment of line 1 or 2
• ECOG PS:0-1,Life expectancy of more than 3 months
• main organs function is normal

Exclusion Criteria:

• prior treatment with Anlotinib or Allergic to drug or its formulation ingredients
• subjects with the gastrointestinal tract, liver and kidney disease of affect drug absorption and metabolism
• CTCAE(4.0) Grade 1 or higher non-remission toxicity induced by any other previous treatments
• patients with pleural effusion or ascites, causing respiratory syndrome (CTCAE Grade 2 or higher dyspnea [Grade 2 dyspnea refers to Shortness of breath with a small amount of activities, affecting Instrumental activities of daily life])
• patients underwent major surgical treatment，open biopsy or significant traumatic injury within 28 days prior to assignment