Duration of Long Acting Muscarinic Antagonist (LAMA) Bronchoprotection Against Methacholine Challenge

Duration of Bronchoprotection of the Long Acting Muscarinic Antagonists Tiotropium and Glycopyrronium Against Methacholine Induced Bronchoconstriction

The study will assess the duration of protection of single doses of 2 different long acting muscarinic antagonists against methacholine induced bronchoconstriction.

Inclusion Criteria:

• male or female asthmatics > 19 years of age
• baseline methacholine PC20 less than or equal to 4mg/ml
• baseline lung function >65% predicted
• non-smoker and less than 10 pack year smoking history

Exclusion Criteria:

• use of anticholinergic within 30 days of Visit 1
• poorly controlled asthma
• pregnant or nursing
• respiratory illness within 4 weeks of Visit 1
• exposure to an agent that triggered asthma worsening (e.g. allergen) within 4 weeks of Visit 1