Animal Fluency (AF) is a scoring system to assess the ability to generate a list of related words.

The score is the number of animals the examinee can name in one minute time. (Minimum = 0, No maximum, higher the better).

Trail making B is a scoring system for the assessment of the mental flexibility, processing speed and executive function. The score is the time (in seconds) it takes for the examinee to draw line segments connecting sequentially from 1-A-2-B-3....all the way to12-L-13. (The lower score means faster speed and means better performance. The minimum is (hypothetically) zero. There is no maximum. However, in some test centers, the maximum allowed time is 200 seconds.

A piece of paper with 6 simple drawings is presented to the subject for 10 seconds. The subject is then asked to draw these drawings from memory. The process is repeated three times to assess visual memory and learning. Each correct drawing scores two pints. Maximum score for three trials is 36. Minimum score is 0. Higher the better.

MoCA is a one page, 30 point cognitive screening test. It test the following cognitive domains:

1. short-term memory (5 points)- two learning trials of five nouns and delayed recall after approximately five minutes.
2. visuospatial abilities - clock-drawing task (3 points) and copy a cube (1 point).
3. executive functions - alternation task abbreviated trail-making B (1 point), and a two-item verbal abstraction task (2 points).
4. attention, concentration, and working memory - a sustained attention task (target detection using tapping; 1 point), a serial subtraction task (3 points), and digits forward and backward (1 point each).
5. language - three-item confrontation naming (3 points), repetition of two sentences (2 points), and verbal fluency (1 point).
6. abstract reasoning - describe the similarity of tasks (2 points).
7. orientation to time and place (6 points). Minimum score: 0. Maximum score: 30. Higher the better.

Total of all reporting groups

sham noise to block the sound of treatment

sham: sham noise to block the sound of stimulation

Changes in Boston Naming Test (BNT) from baseline was analyzed. BNT is a 60 points scoring system. (minimum=0, maximum=60, higher the better).

Sham arm: 18 started, 2 withdrew, 3 did not test properly at baseline, 1 did not show for follow up.

13 sets of data were available at baseline, 13 sets were available at end of treatment, 12 sets were available at follow up. Active arm: 14 started, one withdrew, one did not show for follow up. 13 sets of data were available at baseline, 13 sets were available at end of treatment, 12 sets were available at follow up.

Changes in BDNF plasma levels (pg/ml) from baseline were analyzed after treatment.

BDNF is a plasma biomarker, minimum=0, no maximum. Higher number means more BDNF synthesis).

Sham arm: 18 started, 13 had baseline BDNF collected, two withdrew. 13 sets of data were available at baseline, 11 sets of data were available at end of treatment. Active arm: 14 started, two did not have BDNF collected. 12 sets of data were available at baseline and at end of treatment.

Animal Fluency (AF) is a scoring system to assess the ability to generate a list of related words.

The score is the number of animals the examinee can name in one minute time. (Minimum = 0, No maximum, higher the better).

Sham arm: 18 started, 2 withdrew, 3 did not test properly at baseline, 1 did not show for follow up.

13 sets of data were available at baseline, 13 sets were available at end of treatment, 12 sets were available at follow up. Active arm: 14 started, one withdrew, one did not test properly at end of treatment, one did not show for follow up.

13 sets of data were available at baseline, 12 sets were available at end of treatment, 12 sets were available at follow up.

Trail making B is a scoring system for the assessment of the mental flexibility, processing speed and executive function. The score is the time (in seconds) it takes for the examinee to draw line segments connecting sequentially from 1-A-2-B-3....all the way to12-L-13. (The lower score means faster speed and means better performance. The minimum is (hypothetically) zero. There is no maximum. However, in some test centers, the maximum allowed time is 200 seconds.

Sham arm: 18 started, 2 withdrew, 3 did not test properly at baseline, 1 did not show for follow up.

13 sets of data were available at baseline, 13 sets were available at end of treatment, 12 sets were available at follow up. Active arm: 14 started, one withdrew, one did not show for follow up. 13 sets of data were available at baseline, 13 sets were available at end of treatment, 12 sets were available at follow up.

A piece of paper with 6 simple drawings is presented to the subject for 10 seconds. The subject is then asked to draw these drawings from memory. The process is repeated three times to assess visual memory and learning. Each correct drawing scores two pints. Maximum score for three trials is 36. Minimum score is 0. Higher the better.

Sham arm: 18 started, 2 withdrew, 3 did not test properly at baseline, 1 did not show for follow up.

13 sets of data were available at baseline, 13 sets were available at end of treatment, 12 sets were available at follow up. Active arm: 14 started, one withdrew, one did not show for follow up. 13 sets of data were available at baseline, 13 sets were available at end of treatment, 12 sets were available at follow up.

MoCA is a one page, 30 point cognitive screening test. It test the following cognitive domains:

1. short-term memory (5 points)- two learning trials of five nouns and delayed recall after approximately five minutes.
2. visuospatial abilities - clock-drawing task (3 points) and copy a cube (1 point).
3. executive functions - alternation task abbreviated trail-making B (1 point), and a two-item verbal abstraction task (2 points).
4. attention, concentration, and working memory - a sustained attention task (target detection using tapping; 1 point), a serial subtraction task (3 points), and digits forward and backward (1 point each).
5. language - three-item confrontation naming (3 points), repetition of two sentences (2 points), and verbal fluency (1 point).
6. abstract reasoning - describe the similarity of tasks (2 points).
7. orientation to time and place (6 points). Minimum score: 0. Maximum score: 30. Higher the better.

Sham arm: 18 started, 2 withdrew, 3 did not test properly at baseline, 1 did not show for follow up.

13 sets of data were available at baseline, 13 sets were available at end of treatment, 12 sets were available at follow up. Active arm: 14 started, one withdrew, two did not test properly at end of treatment, one did not show for follow up.

13 sets of data were available at baseline, 11 sets were available at end of treatment, 12 sets were available at follow up.

sham noise to block the sound of treatment Low amplitude electrical stimulation was used to simulate the sensation of RTMS. The electrical stimulation to the scalp can cause mild sense of irritation, which only occurs when the stimulation is turned on.

There were other reported events and were reviewed with the IRB. They were determined to be not related to RTMS treatment.