Substance abuse is a growing problem world wide, and treatment of substance abusers in the perioperative period, especially for emergency operation is challenging. The objectives of this study are to determine the proportions of substance abusers in the trauma patients undergoing emergency operation by preoperative screen, observe the differences of consumption of anesthetics and other medications during perioperative period between substance abusers and non-abusers, as well as postoperative complications, and explore an optimal scheme for substance abusers.

Inclusion Criteria:

• Patients aged 16~70 years；
• Informed consent signed

Exclusion Criteria:

• Aged<16 years or >70 years；
• Refuse to sign consent;
• Other conditions that may preclude the patients from the study, such as language barrier, psychiatric disorders, unable to attend research center for follow up.
• Patients who enrolled to another research study or are taking experimental medication in last 3 months prior to this study.
• Not suitable for the study, after assessment by the investigators.

The trauma patients undergoing emergency operation