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The purpose of the study is to evaluate a 2-3 day treatment probe targeted to improving social gaze behavior in children with fragile X syndrome (FXS). The investigators will use the principles of Applied Behavior Analysis (ABA) to shape appropriate social skills. Importantly, the investigators propose to examine the effects of this treatment probe on brain and behavior.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Social gaze training | Experimental | Appropriate social gaze behavior will be reinforced using the principles of Applied Behavior Analysis. |
|
| No Training | No Intervention | Appropriate social gaze behavior will not be reinforced. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Social gaze training | Behavioral | Appropriate social gaze behavior will be shaped using the principles of Applied Behavior Analysis. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of social gaze aversion recorded during the social challenge | 3 days | |
| Heart rate recorded during the social challenge | 3 days | |
| Total t-score on the Social Responsiveness Scale (SRS) | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Verbal responses and pauses in conversation observed during the social challenge | 3 days | |
| Fractional Amplitude of Low Frequency fluctuations (fALLF) measured in the insular cortex | 3 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stanford University School of Medicine | Stanford | California | 94305 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30153790 | Derived | Gannon CE, Britton TC, Wilkinson EH, Hall SS. Improving social gaze behavior in fragile X syndrome using a behavioral skills training approach: a proof of concept study. J Neurodev Disord. 2018 Aug 28;10(1):25. doi: 10.1186/s11689-018-9243-z. |
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| ID | Term |
|---|---|
| D005600 | Fragile X Syndrome |
| D008607 | Intellectual Disability |
| ID | Term |
|---|---|
| D038901 | X-Linked Intellectual Disability |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| D025064 | Sex Chromosome Disorders |
| D025063 | Chromosome Disorders |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D030342 | Genetic Diseases, Inborn |
| D040181 | Genetic Diseases, X-Linked |
| D020271 | Heredodegenerative Disorders, Nervous System |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |