Effect of Clostridium Butyricum in Treating Irritable Bowel Syndrome

Effect of Clostridium Butyricum in Treating Irritable Bowel Syndrome: A Randomized, Double-blinded,Placebo- Controlled Multicenter Study

Clostridium Butyricum might be an effective drug in treating irritable bowel syndrome

Inclusion Criteria:

• the presence of Rome III criteria for IBS ;
• Aged between 18 and 65 years old

Exclusion Criteria:

• Antibiotic, probiotic or laxative usage within 4 weeks.
• organic gastrointestinal diseases
• Severe systematic disease: diabetes mellitus, hepatic, renal or cardiac dysfunction, thyroid disease or tumor etc.
• pregnancy or lactation.
• previous major or complicated abdominal surgery.
• severe endometriosis and dementia