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| Name | Class |
|---|---|
| Dimension Research | INDUSTRY |
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The Preempt study is likely to help determine the frequency of patients suffering from Minimal Hepatic Encephalopathy (MHE) and are cirrhotics. It will also enable us to know about the Quality of life of these patients.
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| Measure | Description | Time Frame |
|---|---|---|
| Frequency of MHE in Cirrhotic patients | Continuous variables with normal and non-normal distributions would be reported as mean (SD) and median [inter-quartile range (IQR)], respectively. Prevalence of MHE in cirrhotic patients with 95% confidence Interval (CI) will be calculated. Continuous variables between group will compared by using Independent sample t test, and categorical variables will compare by using the chi-square test. | 18 months |
| Measure | Description | Time Frame |
|---|---|---|
| The predisposing factors that might be associated with MHE in all enrolled patients with cirrhosis | Odds Ratios (OR) and their 95% Confidence Intervals (CI) will be estimated using Logistic Regression. The likelihood ratio test used to assess the association between the explanatory variables and the risk of the MHE. Invariable analyses will perform to examine the effect of each variable on the risk of MHE. In multivariate analysis all insignificant variables (p >0.05) will check for their confounding and interaction effects before their removal from the final model. |
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Inclusion Criteria:
Exclusion Criteria:
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Primary Care Clinic/Private Clinic
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| Name | Affiliation | Role |
|---|---|---|
| Raeefuddin Ahmed, MD | Medical Director, Abbott | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Baqai Hospital | Karachi | 74700 | Pakistan | |||
| Fatima Memorial Hospital |
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| ID | Term |
|---|---|
| D006501 | Hepatic Encephalopathy |
| ID | Term |
|---|---|
| D017093 | Liver Failure |
| D048550 | Hepatic Insufficiency |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
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| 18 months |
| Quality of Life (QoL) of patients at baselines | Short Form (SF)-36v2 Quality of Life Questionnaire will be used | 18 months |
| Management of MHE currently in practice | As per practice of the physician/Investigator. Management of MHE will be recorded. The information for medication which will be collected will be Name (preferably the generic name), Dose, Units (form of the medicine), Route and Frequency | 18 months |
| Lahore |
| 54000 |
| Pakistan |
| Lahore General Hospital | Lahore | 54000 | Pakistan |
| Jinnah Hospital Lahore | Lahore | 54550 | Pakistan |
| Doctor's Hospital | Lahore | 54770 | Pakistan |
| Lady Reading Hospital | Peshawar | 25000 | Pakistan |
| D001928 |
| Brain Diseases, Metabolic |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |