This periodized program consisting of 3 resistance exercise sessions per week comprised of high load/low volume, light load/high volume, and moderate load/moderate volume.

The World Health Organization (WHO) Analgesic Ladder will be used to record the use of pain medication by participants at each visit. The three main principles of the WHO analgesic ladder are: "By the clock, by the mouth, by the ladder". "By the clock" means to maintain freedom from pain, drugs should be given "by the clock" or "around the clock" rather than only "on demand" (i.e. PRN). "By the mouth" means the oral route is usually the preferred route for ease of use in a variety of care settings. "By the ladder" means opiates have been given if pain occurs there should be prompt administration of drugs in the following order: non-opiates (e. g. acetaminophen), as necessary, mild opiates (e. g. codeine), and then strong opiates (e. g. morphine or hydromorphone) until the patient is free of pain. Use of pain medication using the WHO analgesic ladder will be completed at baseline and 3 months.

The BPI-SF is a 9-item questionnaire used to assess the severity of pain and the impact of pain on activities of daily living over a recall period of 24 hours. Pain severity is assessed across four sub-scales; 'worst pain', 'least pain', 'average pain' and 'current pain'. A pain score for each subscale is presented separately. Scales are rated on a scale of 0 to 10 (0 = no pain; 10 = pain as bad as one can imagine). A composite score for pain severity is calculated as the mean of the four severity items. Question 9 comprises a 7-item interference scale. Questions assess the level to which pain interferes with general activity, walking, work, mood, enjoyment of life, relations with others and sleep on a scale of 0 to 10 (0 = does not interfere; 10 = completely interferes). Mean interference score will be calculated as an average of the seven subparts of question 9 where at least four of the seven items are completed. Participants will complete the assessment at baseline and 3 months.

Participants objective physical function will be assessed using a combination of the the steep ramp (short maximal exercise test that is performed on a cycle ergometer), repeated chair rise, stair climb, and 400 meter (m) walk.

Strength assessments will comprise one repetition maximum (RM)chest press, leg press and seated row. One method will be chosen as the primary method, based on the availability of resistance equipment however, alternative methods will be used, if not appropriate for the patient based on the location of metastasis. The 1-RM is defined as the highest load that can be lifted through full range of movement at one time. Participant suitability to perform each test will be dependent on the site of the metastasis. The decision to either complete or not complete 1 repetition maximum (RM) testing at each site will be decided by the exercise physiologist / therapist performing the test in consultation with the participant's treating physician using an exercise checklist completed by the physician, prior to any testing, which will indicate which exercises to avoid. Any exercise during testing which causes a participant issues will be stopped.

The functional domains measure the quality of life in Physical functioning, Role functioning, Emotional functioning, Cognitive functioning, Social functioning. Scores consists of responses to items with responses ranging from 1="Not at all" to 4="Very Much". The raw score is calculated by estimating the mean of the items that make up each domains with a resulting total range of 1 - 4. These scores are then transformed to standardized scale score, so that scores range from 0 to 100. A high score for the functional domains represents a high level of functioning. Participants will complete the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 at baseline and 3 months.

EQ-5D is a standardized instrument for measuring generic health status. The health status is measured in terms of five dimensions (5D); mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. The respondents self-rate their level of severity for each dimension by selecting one of the following responses: no problems (0), slight problems (1), mild problems (2), moderate problems (3), or severe problems (4) with a particular dimension. Lower scores indicate less issues/problems with that particular health dimension. Participants will complete the EQ-5D at baseline and 3 months.

The EPIC-26 measures the impact of quality of life issues across 5 prostate cancer specific domains: Urinary incontinence, Urinary irritation, Bowel function, Sexual function, and Hormonal function and overall total quality of life. Response options for each EPIC item form a Likert scale, and the raw score of each item is then transformed linearly to a 0-100 scale. Multiple items are combined and then averaged to form the domain scores and total score at each time point also ranging from 0-100, with higher scores representing better health related quality of life (HRQOL). Participants will complete the EPIC-26 at baseline and 3 months.

The Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-F) is a 13-item measure that assessing the consequences of fatigue and its impact on participants quality of life. Each item is rated on a 5-point Likert scale ranging from 0 = "Not at all" to 4 = "Very much" with a total score range of 0-52, and higher scores indicating a greater impact of fatigue on . Participants will complete the FACIT-F at baseline and 3 months.

The Spielberger et. al STAI is a commonly used measure of trait and state anxiety. It can be used in clinical settings to diagnose anxiety and to distinguish it from depressive syndromes. It has 20 items for assessing trait anxiety and 20 for state anxiety for a total of 40 items. State anxiety items include: "I am tense; I am worried" and "I feel calm; I feel secure." Trait anxiety items include: "I worry too much over something that really doesn't matter" and "I am content; I am a steady person." All items are rated on a 4-point scale (e.g., from "1=Almost Never" to 4="Almost Always") with a maximum score range of 40-160 when all 40 items are administered Higher scores indicate greater anxiety. Participants will complete the State Anxiety Inventory at baseline and 3 months.

The Center for Epidemiological Studies-Depression (CES-D) is a 20-item measure that asks caregivers to rate how often over the past week they experienced symptoms associated with depression, such as restless sleep, poor appetite, and feeling lonely. Response options range from 0 to 3 for each item (0 = Rarely or None of the Time, 1 = Some or Little of the Time, 2 = Moderately or Much of the time, 3 = Most or Almost All the Time). Scores range from 0 to 60, with high scores indicating greater depressive symptoms. Participants will complete the Center for Epidemiological Studies Depression Scale at baseline and 3 months.

The Pittsburgh Sleep Quality Index (PSQI) is a self-rated questionnaire which assesses sleep quality and disturbances over a 1-month time interval. Nineteen individual items generate seven "component" scores: subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleeping medication, and daytime dysfunction. The sum of scores for these seven components yields one global score with a possible range of 0-21 points, with lower global scores indicating better sleep overall. Participants will complete the Pittsburgh Sleep Quality Index at baseline and 3 months.

FACT-G SFWB scores range from 0 to 28, with a higher score reflecting better social and familial well-being.

PFS will be defined as the time from randomization to the date of disease progression + 1 day. Participants who have not progressed at the time of the analysis will be censored on the last date of contact. Participants with no data after randomization will be censored on the day of randomization + 1 day. An intent-to-treat approach will be used to analyze PFS. Data on PFS will be obtained through review of patient medical records at end of study, 1 year, and 2 years. Progression will be determined by the treating physician, and may include any of the following, based on Prostate Cancer Clinical Trials Working Group 3 (PCWG 3) and Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria

Overall Survival and mortality data will be collected at end of study, one year, and two years through medical records and death records.

Time to first occurrence of SSE will be defined as the time from randomization to documentation of any of following (whichever occurs first) + 1 day: (1) Use of external beam radiation therapy to relieve bone pain, (2) occurrence of new symptomatic pathological bone fractures that may be vertebral or nonvertebral, asymptomatic compression fractures detected by radiology review only will not be considered a SSE, (3) Spinal cord compression, (4) Change in antineoplastic therapy to treat bone pain, (5) Surgical intervention to treat bone pain. Patients who do not experience a SSE will be censored on the date on which they were last known to be event-free. Adverse events, concomitant medications, concomitant treatment, or survival follow-up case report forms (CRFs) and the participant's medical record will be the source of these findings.