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The purpose of this study is to determine whether combined endurance and resistance training can improve muscle strength in children and adolescents with cancer during the intensive treatment phase.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise group | Experimental | Exercise training during intensive medical treatment |
|
| Control group | No Intervention | Usual Care |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise Training | Behavioral | Exercise training during intensive medical treatment. Training mainly composed of endurance and resistance exercises. 3 to 5 times per week for six weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| Muscle strength: lower limb | Lower limb muscle strength measured by the load (kg) sustained in one repetition maximum test | Six weeks (pre-post intervention) |
| Measure | Description | Time Frame |
|---|---|---|
| Muscle strength: upper limb | Upper limb muscle strength measured by the load (kg) sustained in one repetition maximum test | Six weeks (pre-post intervention) |
| Biomarker in Blood | Immune status and metabolic status |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Johannes-Gutenberg-University | Mainz | Rhineland-Palatinate | 55131 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34860287 | Derived | Winker M, Stossel S, Neu MA, Lehmann N, El Malki K, Paret C, Joisten N, Bloch W, Zimmer P, Faber J. Exercise reduces systemic immune inflammation index (SII) in childhood cancer patients. Support Care Cancer. 2022 Apr;30(4):2905-2908. doi: 10.1007/s00520-021-06719-3. Epub 2021 Dec 3. | |
| 32582585 | Derived | Stossel S, Neu MA, Wingerter A, Bloch W, Zimmer P, Paret C, Malki KE, Baumann FT, Russo A, Henninger N, Lehmann N, Otto H, Faber J. Benefits of Exercise Training for Children and Adolescents Undergoing Cancer Treatment: Results From the Randomized Controlled MUCKI Trial. Front Pediatr. 2020 Jun 5;8:243. doi: 10.3389/fped.2020.00243. eCollection 2020. |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| At the beginning of the intervention and three and six weeks after the beginning. Comparing the two time points inbetween study groups |
| Body composition | Bioelectrical Impedance Analysis | Six weeks (pre-post intervention) |
| Six-minute-walk performance | Six weeks (pre-post intervention) |
| Fatigue | Pediatric Quality of Life Inventory (PedsQL) Multidimensional Fatigue Scale | six weeks (pre-post intervention) |
| Quality of Life | KINDL: health related quality of life questionnaire | Six weeks (pre-post intervention) |
| Cardiorespiratory performance | Ergospirometry | Six weeks (pre-post intervention) |