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Various indexes have been proposed to quantify both pulmonary emphysema and airways disease on chest CT scans. It is unknown whether these indexes should be consider in absolute values or as compared to predicted normal values. The purposes of the present study is thus : a) to measure these indexes at CT in healthy volunteers; b) to investigate their relations with gender, height and weight.
87 healthy volunteers performed consecutively a low-dose chest CT scan and pulmonary function tests:
On chest CT scans, indexes reflecting pulmonary emphysema and airways measurements have been computed by using dedicated softwares. Each of our three readers performed two reading sessions.
Relative area of lung parenchyma with attenuation value less than -960 Hounsfield Units; luminal area and wall thickness in third and fourth generations airways were recorded.
Pulmonary function tests were performed: vital capacity, forced vital capacity , functional residual capacity, total lung capacity, residual volume, forced expiratory volume in one second, and diffusion lung capacity for carbon monoxide were recorded (either in absolute values and percentage of predicted values).
CT indexes were compared with gender, height and weight.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy Volunteers | Inclusion criteria:
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Low-dose chest CT scans | Radiation | Supine chest CT scan after full inspiration. Acquisition parameters: (Topogram 35 mA 120 kV 512 mm length) 35 quality ref mAs with care-dose ON 120 kV Pitch 1.4 Rotation time 0.33 s Acquired images 64 x 0.6 mm |
| Measure | Description | Time Frame |
|---|---|---|
| CT index - RA960 (%) | From acquired data, images were reconstructed using a soft algorithm. On these soft images, the relative area of lung parenchyma with attenuation value less than -960 Hounsfield Units was computed (expressed in %), as an index representative of pulmonary emphysema extent. | 4 hours |
| CT index - LA3rd (mm2) | From acquired data, images were reconstructed using a high resolution algorithm. On these high-resolution images, the airway lumen was measured in third generations of airways (expressed in mm2). | 4 hours |
| CT index - LA4th (mm2) | From acquired data, images were reconstructed using a high resolution algorithm. On these high-resolution images, the airway lumen was measured in fourth generations of airways (expressed in mm2). | 4 hours |
| CT index - WT3rd (mm) | From acquired data, images were reconstructed using a high resolution algorithm. On these high-resolution images, the airway wall was measured in third generations of airways (expressed in mm). | 4 hours |
| CT index - WT4th (mm) | From acquired data, images were reconstructed using a high resolution algorithm. On these high-resolution images, the airway wall was measured in fourth generations of airways (expressed in mm). | 4 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Pulmonary function tests - VC (l) | Vital capacity was measured (expressed in l). | 4 hours |
| Pulmonary function tests - FVC (l) | Forced vital capacity was measured (expressed in l). |
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Inclusion Criteria:
Exclusion Criteria:
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Healthy Volunteers
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| Name | Affiliation | Role |
|---|---|---|
| Pierre Alain GEVENOIS, MD, PhD | Erasme University Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Erasme University Hospital | Brussels | Brussels Capital | 1070 | Belgium |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16424242 | Background | Madani A, Zanen J, de Maertelaer V, Gevenois PA. Pulmonary emphysema: objective quantification at multi-detector row CT--comparison with macroscopic and microscopic morphometry. Radiology. 2006 Mar;238(3):1036-43. doi: 10.1148/radiol.2382042196. Epub 2006 Jan 19. | |
| 17392257 | Background | Madani A, De Maertelaer V, Zanen J, Gevenois PA. Pulmonary emphysema: radiation dose and section thickness at multidetector CT quantification--comparison with macroscopic and microscopic morphometry. Radiology. 2007 Apr;243(1):250-7. doi: 10.1148/radiol.2431060194. |
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| ID | Term |
|---|---|
| D004646 | Emphysema |
| D056151 | Airway Remodeling |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D020763 | Pathological Conditions, Anatomical |
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| 4 hours |
| Pulmonary function tests - FRC (l) | Functional residual capacity capacity was measured (expressed in l). | 4 hours |
| Pulmonary function tests - TLC (l) | Total lung capacity was measured (expressed in l). | 4 hours |
| Pulmonary function tests - RV (l) | Residual volume was measured (expressed in l). | 4 hours |
| Pulmonary function tests - FEV1 (l) | Forced expiratory volume in one second was measured (expressed in l). | 4 hours |
| Pulmonary function tests - DLCO (ml/min/ mmHg) | Diffusion lung capacity for carbon monoxide was measured (expressed in ml/min/ mmHg) | 4 hours |
| 22993219 | Background | Hackx M, Bankier AA, Gevenois PA. Chronic obstructive pulmonary disease: CT quantification of airways disease. Radiology. 2012 Oct;265(1):34-48. doi: 10.1148/radiol.12111270. |
| 25989594 | Background | Hackx M, Gyssels E, Severo Garcia T, De Meulder I, Alard S, Bruyneel M, Van Muylem A, Ninane V, Gevenois PA. Chronic Obstructive Pulmonary Disease: CT Quantification of Airway Dimensions, Numbers of Airways to Measure, and Effect of Bronchodilation. Radiology. 2015 Dec;277(3):853-62. doi: 10.1148/radiol.2015140949. Epub 2015 May 19. |