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The purpose of this study is to explore the neurohumoral mechanism of deferent frequency TEAS pretreatment.
Patients were randomly assigned to three groups, receiving TEAS 30min before anesthesia. The frequency of high frequency group is set to 10/50HZ, low frequency group is 2/10HZ, and the fake stimulation group only attach electrodes without electric current. Acupoint selection is bilateral Neiguan points(PC6). Venous blood is collected 4ml before and immediately after TEAS respectively. Heart rate variability is monitored continuously during the 30min TEAS. The adverse events recorded.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 2/10HZ TEAS pretreatment | Experimental | Patients were given 30min of 2/10HZ TEAS before anesthesia |
|
| 10/50HZ TEAS pretreatment | Experimental | Patients were given 30min of 10/50HZ TEAS before anesthesia |
|
| fake stimulation | Sham Comparator | Patients were only attached electrodes without electric current |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| TEAS (transcutaneous electrical acupoint stimulation) | Device | 2/10HZ Electric stimulation was given through electrode attached to specific acupoints |
|
| Measure | Description | Time Frame |
|---|---|---|
| Plasma concentration of epinephrine(ng/L) | change of TEAS 0 and 30 minutes | |
| Plasma concentration of norepinephrine(ng/L) | change of TEAS 0 and 30 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Heart rate variability | During 30min TEAS | |
| plasma concentration of glucocorticoid(μg/L) | change of TEAS 0 and 30 minutes | |
| plasma concentration of aldosterone(ng/L) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Qiang Wang | Contact | 86-29-84775343 | wangqiang@fmmu.edu.cn |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26170347 | Background | Lu Z, Dong H, Wang Q, Xiong L. Perioperative acupuncture modulation: more than anaesthesia. Br J Anaesth. 2015 Aug;115(2):183-93. doi: 10.1093/bja/aev227. |
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| ID | Term |
|---|---|
| D007022 | Hypotension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| TEAS (transcutaneous electrical acupoint stimulation) | Device | 10/50HZ Electric stimulation was given through electrode attached to specific acupoints |
|
| fake stimulation | Device | Patients were only attached electrodes without electric current |
|
| change of TEAS 0 and 30 minutes |
| plasma concentration of renin(ng/L) | change of TEAS 0 and 30 minutes |
| plasma concentration of β-endorphin(ng/L) | change of TEAS 0 and 30 minutes |