Neurohumoral Mechanism of Deferent Frequency Transcutaneous Electrical Acupoint Stimulation(TEAS)

Neurohumor Mechanism of Deferent Frequency Transcutaneous Electrical Acupoint Stimulation(TEAS): A Prospective, Randomized Controlled Trial

The purpose of this study is to explore the neurohumoral mechanism of deferent frequency TEAS pretreatment.

Patients were randomly assigned to three groups, receiving TEAS 30min before anesthesia. The frequency of high frequency group is set to 10/50HZ, low frequency group is 2/10HZ, and the fake stimulation group only attach electrodes without electric current. Acupoint selection is bilateral Neiguan points(PC6). Venous blood is collected 4ml before and immediately after TEAS respectively. Heart rate variability is monitored continuously during the 30min TEAS. The adverse events recorded.

Inclusion Criteria:

• Age 18yrs-65yrs
• ASA 1-2
• Scheduled for elective operation under general anesthesia
• BMI 18-30kg/m2
• Informed consented

Exclusion Criteria:

• Contraindications to TEAS
• Communication difficulty with researchers
• Addicted to alcohol, analgesics or other drugs
• Cardiac insufficiency or high blood pressure without controlled
• Hepatic or renal dysfunction
• Participate in the other clinical trial 3 month before the enrollment