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| Name | Class |
|---|---|
| International Centre for Diarrhoeal Disease Research, Bangladesh | OTHER |
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Municipal water networks within industrialized countries typically rely on centralized treatment to manage piped water quality. Optimal water quality at the tap, however, requires well-maintained piped distribution networks, and performs best when piped systems are fully pressurized. In low-income cities such as Dhaka, water distribution networks are inadequately maintained and typically supply intermittent service; as such, they are vulnerable to recontamination during negative pressure events. Among populations accessing these types of improved water sources in urban settings (e.g. shared taps), it is unknown if consistent treatment to provide chlorinated water at the point of collection would have a significant health benefit. Furthermore, almost all previous studies of water treatment interventions in low-income countries have been unblinded with self-reported diarrhea as the main outcome, casting doubt that reported impacts of water disinfection on diarrhea are not due entirely to social desirability bias. Stanford University in collaboration with icddr,b will conduct a randomized evaluation to assess the impact on access to automatically chlorinated water on water quality and child health.
Investigators will conduct a blinded cluster randomized controlled trial to evaluate the health and economic impacts of having access to automatically chlorinated water. The unit of randomization will be shared water points that typically serve 20-200 households. Shared water points connected to holding tanks compatible with the water treatment technology, and serving more than 4 households with at least one child under five, will be identified. Households accessing eligible water points as their primary drinking water source will be enrolled before installation of chlorine devices, and a baseline survey will be conducted of water quality, diarrhea prevalence, and health care expenditures. Following this baseline, households will be randomly assigned to control or treatment groups. The chlorination devices will be installed at the treatment group water points, while a doser containing vitamin C (and no chlorine), will be installed in the control group. The free chlorine dosing target will be below <1ppm to preserve blinding. All households will be surveyed every 2-3 months for a total follow up period of 14-16 months (5-7 survey rounds, budget permitting).
Objectives:
Analysis:
The primary analyses will be intent-to-treat (investigators will analyze differences in outcomes between the treatment and control groups, with groups defined by their random allocation). Investigators will also conduct a secondary analysis comparing outcomes between intervention and control, where the intervention group is defined as those households that had free chlorine residual detected in their stored drinking water (treated on the treated analysis).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Chlorination | Experimental | Device: Water chlorination by the Flogenic Primary drinking water source will be outfitted with automatic dosing device supplied with chlorine tablets. The device is called the Flogenic. |
|
| Control | Placebo Comparator | Active control: Vitamin C dosing into water. Primary drinking water source will be outfitted with automatic dosing device supplied with vitamin C tablets. The device is not commercially available. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Water chlorination by the Flogenic | Device | The chlorine doser delivers a constant amount of chlorine into water as it flows into a holding tank. The water is then piped to public and private taps. |
| Measure | Description | Time Frame |
|---|---|---|
| Diarrhea longitudinal prevalence | 1-week recall period, case definition is 3 or more loose/watery bowel movements in 24 hours | Measured every 2-3 months for 16 months post baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Weight-for-age-z-score | Weight-for-age z-score among children under five years | Measured every 2-3 months for 16 months post baseline |
| Height-for-age-z-score | Height-for-age z-score among children under five |
| Measure | Description | Time Frame |
|---|---|---|
| Microbial water quality | Colony forming units of the fecal indicator bacteria, E. coli | Measured monthly among a subset of households, for 16 months post baseline |
| Chlorine residual in household stored drinking water |
Inclusion Criteria:
Exclusion Criteria:
Note: New births and children under 60 months that migrate into compounds accessing the enrolled water points for drinking water will be enrolled into the study.
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| Name | Affiliation | Role |
|---|---|---|
| Stephen Luby, MD | Stanford University | Principal Investigator |
| Amy Pickering, PhD | Stanford University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tongi and Dhaka Uddan | Tongi/Dhaka | Gazipur | Bangladesh |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31402005 | Derived | Pickering AJ, Crider Y, Sultana S, Swarthout J, Goddard FG, Anjerul Islam S, Sen S, Ayyagari R, Luby SP. Effect of in-line drinking water chlorination at the point of collection on child diarrhoea in urban Bangladesh: a double-blind, cluster-randomised controlled trial. Lancet Glob Health. 2019 Sep;7(9):e1247-e1256. doi: 10.1016/S2214-109X(19)30315-8. |
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| ID | Term |
|---|---|
| D003967 | Diarrhea |
| D003141 | Communicable Diseases |
| ID | Term |
|---|---|
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007239 | Infections |
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| Active control, vitamin C dosing into water | Device | The control group will receive a vitamin C dosing device that looks identical to the intervention chlorine doser installed in the holding tank that feeds their shared water access point. |
|
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| Measured at baseline and 16 months after baseline |
| Respiratory illness longitudinal prevalence | one week recall period, symptoms include congestion, cough, difficulty breathing | Measured every 2-3 months for 16 months post baseline |
| C-reactive protein | Measured at baseline and conclusion of study (16 months post baseline) among children under five |
| total immunoglobin G (IgG) | Measured at baseline and conclusion of study (16 months post baseline) among children under five |
| Prevalence and number of enteric pathogens | Measured 6-12 months after intervention delivery among children under five |
| Caregiver defined diarrhea | 1-week recall period, defined with local Bengali word for diarrhea | Measured every 2-3 months for 16 months post baseline |
Free chlorine residual in ppm
| Measured every 2-3 months for 16 months post baseline |
| health related treatment and associated cost | Measured every 2-3 months for 16 months post baseline |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |