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The IRON-MPP is a prospective multicenter, observational registry designed to collect clinical and device data from a large cohort of HF patients treated in clinical practice with a CRT-D device with the ability to deliver Multi Point Pacing.
The purpose of the Registry is to collect data on how MPP-devices are being used by physicians in order to better understand how to improve the clinical care of patients and effectiveness of MPP therapy.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CRT-D | Device | HF patients treated in clinical practice with a CRT-D device |
| Measure | Description | Time Frame |
|---|---|---|
| Left ventricular ejection fraction | Changes in Left ventricular ejection fraction | 6 Months |
| Measure | Description | Time Frame |
|---|---|---|
| Heart Failure Hospitalizations | 12 months | |
| Appropriate device interventions | Number of participants with appropriate device interventions (anti-tachycardia pacing or shock) | 12 months |
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Inclusion Criteria:
- Patients implanted with a St. Jude Medical CRT-D system with MPP capability
Exclusion Criteria:
- Patients currently participating in any other clinical investigation
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HF patients treated in clinical practice with a CRT-D device with the ability to deliver MPP
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| Name | Affiliation | Role |
|---|---|---|
| Giovanni Forleo | Policlinico Tor Vergata | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ospedale Santa Maria della Misericordia | Rovigo | Italy | ||||
| Casa Sollievo della Sofferenza |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27189954 | Derived | Forleo GB, Santini L, Giammaria M, Potenza D, Curnis A, Calabrese V, Ricciardi D, D'agostino C, Notarstefano P, Ribatti V, Morani G, Mantica M, Di Biase L, Bertaglia E, Calo L, Zanon F. Multipoint pacing via a quadripolar left-ventricular lead: preliminary results from the Italian registry on multipoint left-ventricular pacing in cardiac resynchronization therapy (IRON-MPP). Europace. 2017 Jul 1;19(7):1170-1177. doi: 10.1093/europace/euw094. |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| D014693 | Ventricular Fibrillation |
| D017180 | Tachycardia, Ventricular |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D001145 | Arrhythmias, Cardiac |
| D010335 | Pathologic Processes |
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| Echocardiographic changes | Left ventricular end systolic volume | 12 months |
| QRS Duration | Changes in QSR duration between MPP and conventional biventricular pacing | Baseline and six months |
| San Giovanni Rotondo |
| Italy |
| Ospedale Maria Vittoria | Torino | Italy |
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D013610 | Tachycardia |
| D000075224 | Cardiac Conduction System Disease |