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| Name | Class |
|---|---|
| Mackay Memorial Hospital | OTHER |
| Li Shin Hospital | OTHER |
| Chang Gung Memorial Hospital | OTHER |
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The purpose of this prospective study is to evaluate whether DNA methylation can be applied in cervical cancer screening.
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| Measure | Description | Time Frame |
|---|---|---|
| Performance of DNA methylation in identification of CIN3 or worse. | Patient's information, including clinical diagnosis and the molecular testing results etc., will be collected. Performances of the screening tools will be compared. | 3 years |
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Inclusion Criteria:
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Investigators plan to recruit 5,000 women to participate this study in Taiwan. Papanicolaou test, high-risk HPV typing and DNA methylation will be co-tested. It is expected to find an optimal solution for molecular cervical cancer screening. The participant will be recruited by Mackay Memorial Hospital, Chang Gung Memorial Hospital, and Lin-Hsin Hospital.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Chien-Ping Hung | Contact | +886-2-2696-3518 | 15 | apple@istatbio.com |
| Hsiu-yuan Tsao | Contact | +886-2-2696-3518 | 14 | hytsao@istatbio.com |
| Name | Affiliation | Role |
|---|---|---|
| Yuh-cheng Yang, MD | Mackay Memorial Hospital | Study Chair |
| Shih-chu Ho, MD | Li Shin Hospital | Principal Investigator |
| Ting-Chang Chang, MD., MPH. |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mackay Memorial Hospital, Linkou Chang Gung Memorial Hospital, Lin-Shin Medical Corporation Lin-Shin Hosptial | Recruiting | Taipei, Taoyuan, and Taichung | Taiwan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16434596 | Background | Sova P, Feng Q, Geiss G, Wood T, Strauss R, Rudolf V, Lieber A, Kiviat N. Discovery of novel methylation biomarkers in cervical carcinoma by global demethylation and microarray analysis. Cancer Epidemiol Biomarkers Prev. 2006 Jan;15(1):114-23. doi: 10.1158/1055-9965.EPI-05-0323. | |
| 18398837 | Background | Lai HC, Lin YW, Huang TH, Yan P, Huang RL, Wang HC, Liu J, Chan MW, Chu TY, Sun CA, Chang CC, Yu MH. Identification of novel DNA methylation markers in cervical cancer. Int J Cancer. 2008 Jul 1;123(1):161-7. doi: 10.1002/ijc.23519. |
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| ID | Term |
|---|---|
| D002578 | Uterine Cervical Dysplasia |
| D002583 | Uterine Cervical Neoplasms |
| ID | Term |
|---|---|
| D011230 | Precancerous Conditions |
| D009369 | Neoplasms |
| D002577 | Uterine Cervical Diseases |
| D014591 | Uterine Diseases |
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cervical cells
| Chang Gung Memorial Hospital |
| Principal Investigator |
| Chih-Long Chang, MD, Ph.D. | Mackay Memorial Hospital | Principal Investigator |
| 20442585 | Background | Huang TH, Lai HC, Liu HW, Lin CJ, Wang KH, Ding DC, Chu TY. Quantitative analysis of methylation status of the PAX1 gene for detection of cervical cancer. Int J Gynecol Cancer. 2010 May;20(4):513-9. doi: 10.1111/IGC.0b013e3181c7fe6e. |
| 20564139 | Background | Lai HC, Lin YW, Huang RL, Chung MT, Wang HC, Liao YP, Su PH, Liu YL, Yu MH. Quantitative DNA methylation analysis detects cervical intraepithelial neoplasms type 3 and worse. Cancer. 2010 Sep 15;116(18):4266-74. doi: 10.1002/cncr.25252. |
| 21710649 | Background | Chao TK, Ke FY, Liao YP, Wang HC, Yu CP, Lai HC. Triage of cervical cytological diagnoses of atypical squamous cells by DNA methylation of paired boxed gene 1 (PAX1). Diagn Cytopathol. 2013 Jan;41(1):41-6. doi: 10.1002/dc.21758. Epub 2011 Jun 27. |
| 11241260 | Background | Krane JF, Granter SR, Trask CE, Hogan CL, Lee KR. Papanicolaou smear sensitivity for the detection of adenocarcinoma of the cervix: a study of 49 cases. Cancer. 2001 Feb 25;93(1):8-15. |
| D005831 |
| Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
| D014594 | Uterine Neoplasms |
| D005833 | Genital Neoplasms, Female |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |