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Paralympians competing in wheelchair sports may experience a very high glycolytic demand (and therefore acidotic environment) in their upper-body muscles, particularly in high-intensity disciplines. Previous studies from our group have shown that upper-body exercise is very sensitive to the ergogenic effects of β-alanine supplementation and to other nutritional supplements capable of increasing buffering capacity. In line with this, have shown that upper-body muscle groups benefit more from artificially induced alkalosis than lower-body muscle groups. Although β-alanine appears to be an interesting and potential ergogenic supplement for paralympians, no study to date has assessed its potential in wheelchair athletes.In this study, we will evaluate the effects of β-alanine supplementation on upper-body performance in wheelchair athletes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | 800 mg of dextrose, four times per day, during 28 days. |
|
| Beta-alanine | Experimental | 800 mg of beta-alanine, four times per day, during 28 days. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Beta-alanine | Dietary Supplement |
| ||
| Dextrose |
| Measure | Description | Time Frame |
|---|---|---|
| Exercise performance (Time to exhaustion test) | Time to exhaustion test performed on arm crank ergometer | 28 days |
| Muscle carnosine content before and after supplementation | Assessed by muscle biopsy samples before performance tests | 28 days |
| Measure | Description | Time Frame |
|---|---|---|
| Muscle carnosine content in trained (deltoid) vs. untrained (vastus lateralis) muscles | Deltoids microbiopsy and vastus lateralis biopsy | 28 days |
| Blood pH. | 1 mL venous blood sample |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Guilherme Artioli, PhD | Contact | 55 11 30913096 | artioli@usp.br |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| School of Physical Education and Sports, University of Sao Paulo | São Paulo | São Paulo | 05508-030 | Brazil |
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| ID | Term |
|---|---|
| D013119 | Spinal Cord Injuries |
| ID | Term |
|---|---|
| D013118 | Spinal Cord Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020196 | Trauma, Nervous System |
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| ID | Term |
|---|---|
| D015091 | beta-Alanine |
| D005947 | Glucose |
| ID | Term |
|---|---|
| D000409 | Alanine |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
| D006601 | Hexoses |
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|
| 5 minutes after performance tests |
| Safety of beta-alanine supplementation measured by complete hemogram analysis | 28 days |
| D014947 | Wounds and Injuries |
| D009005 |
| Monosaccharides |
| D000073893 | Sugars |
| D002241 | Carbohydrates |