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This study aims to assess the need to stop Aspirin before elective laparoscopic inguinal hernia repair. It will consist of 2 arms: patients who continue to take Aspirin perioperatively and patients who stop Aspirin 5-7 days before the surgery.
This study aims to assess the need to stop Aspirin before elective laparoscopic inguinal hernia repair. It will consist of 2 arms: patients who continue to take Aspirin perioperatively and patients who stop Aspirin 5-7 days before the surgery. Simple randomization will be performed and allocation is via closed envelope method. The surgeon will be blinded regarding the usage of Aspirin. The primary outcome is the incidence of post-operative hematoma formation within the first 24 hours after surgery. The secondary outcomes are the incidence of post-operative seroma formation within 24 hours, the incidence of post-operative hematoma requiring intervention (including blood transfusion, percutaneous drainage and surgical hemostasis) within 30 days, pain at regular intervals and the incidence of other post-operative complications.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients who stop Aspirin perioperatively | Active Comparator | Patients undergoing laparoscopic inguinal hernia repair will stop Aspirin 5-7 days before the surgery |
|
| Patients who continue Aspirin perioperatively | Experimental | Patients undergoing laparoscopic inguinal hernia repair will continue on Aspirin perioperatively |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Laparoscopic inguinal hernia repair with perioperative Aspirin | Procedure | Patients undergoing laparoscopic inguinal hernia repair will continue on Aspirin perioperatively |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of hematoma | Postoperative scrotal or groin hematoma (not including skin bruising) | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of seroma | Postoperative scrotal or groin seroma | 24 hours |
| Incidence of hematoma requiring intervention | Including blood transfusion, percutaneous drainage or surgical hemostasis |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Davide Lomanto, MD PhD | Contact | +6567725903 | surdl@nus.edu.sg |
| Name | Affiliation | Role |
|---|---|---|
| Davide Lomanto, MD PhD | National University Hospital, Singapore | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National University Hospital | Recruiting | Singapore | 119074 | Singapore |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40616699 | Derived | Tan L, Yeow M, Fatt SLK, Parameswaran R, Mahipal M, Loo L, Wijerathne S, Lomanto D. Cessation vs no cessation of acetylsalicylic acid preoperatively in laparoscopic totally extraperitoneal inguinal hernia repair (CAPTAIN): final report from a multi-center, single-blinded, randomized-controlled trial. Hernia. 2025 Jul 5;29(1):221. doi: 10.1007/s10029-025-03418-4. |
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| ID | Term |
|---|---|
| D006552 | Hernia, Inguinal |
| ID | Term |
|---|---|
| D046449 | Hernia, Abdominal |
| D006547 | Hernia |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Laparoscopic inguinal hernia repair without perioperative Aspirin | Procedure | Patients undergoing laparoscopic inguinal hernia repair will stop Aspirin 5-7 days before the surgery |
|
| 30 days |