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Effect of Melatonin on Body Composition, Glucose Metabolism and Lipid Metabolism.
The effect of Melatonin on Body Composition, Glucose Metabolism and Lipid Metabolism in patient with obesity and acanthuses nigrican.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Melatonin | Experimental | Take one table at bedtime. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| melatonin | Dietary Supplement | Take one tablet (containing melatonin 3mg, calcium 52mg, vitamin B6 5mg) at bedtime everyday for 12 weeks. |
|
| Measure | Description | Time Frame |
|---|---|---|
| insulin resistance index | HOMA-IR:serum fasting insulin(mmol/L) × serum fasting glucose(mmol/L)/22.5 | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Blood pressure | Systolic blood pressure (mmHg) and diastolic blood pressure (mmHg) | 12 weeks |
| Body weight | Body weight (kg) | 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Shen Qu, Ph.D | Shanghai 10th People's Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai Tenth People' Hospital | Shanghai | Shanghai Municipality | 200072 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29706998 | Derived | Sun H, Wang X, Chen J, Gusdon AM, Song K, Li L, Qu S. Melatonin Treatment Improves Insulin Resistance and Pigmentation in Obese Patients with Acanthosis Nigricans. Int J Endocrinol. 2018 Mar 12;2018:2304746. doi: 10.1155/2018/2304746. eCollection 2018. |
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| ID | Term |
|---|---|
| D000052 | Acanthosis Nigricans |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D008548 | Melanosis |
| D017495 | Hyperpigmentation |
| D010859 | Pigmentation Disorders |
| D012871 | Skin Diseases |
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| ID | Term |
|---|---|
| D008550 | Melatonin |
| ID | Term |
|---|---|
| D014363 | Tryptamines |
| D007211 | Indoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
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| Body fat | Body fat (%) | 12 weeks |
| Neck circumference | Neck circumference (cm) | 12 weeks |
| Waist circumference | Waist circumference (cm) | 12 weeks |
| Total Cholesterol | Total Cholesterol (mmol/L) | 12 weeks |
| Triglyceride | Triglyceride (mmol/L) | 12 weeks |
| Low Density Lipoprotein | Low Density Lipoprotein (mmol/L) | 12 weeks |
| High Density Lipoprotein | High Density Lipoprotein (mmol/L) | 12 weeks |
| D017437 |
| Skin and Connective Tissue Diseases |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006571 | Heterocyclic Compounds |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |