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The purpose of this study is to demonstrate that changing aligners weekly provides similar results to changing aligners every two weeks.
The Invisalign® System consists of a series of clear plastic aligners that are intended to replace conventional wire and bracket technology for many orthodontic cases. Each custom manufactured aligner exerts gentle, continuous forces to move teeth incrementally from their original state to a final, treated state. The aligners are designed to optimally move each tooth at a speed that follows physiologic principles. The purpose of this study is to demonstrate that changing aligners weekly provides similar results to changing aligners every two weeks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Teen | < 17 years of age |
| |
| Adult | 17 years of age or older |
| |
| Adult with Primer Aligners | 17 years of age or older This group will get Primer Aligners |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Invisalign | Device |
|
| Measure | Description | Time Frame |
|---|---|---|
| Planned to Final Tooth Position | Test vs Historical Control Group | Through study completion, an average of 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Treatment time | Length of treatment | Through study completion, an average of 2 years |
| Subject Quality of Life | Assessment of QoL | Through study completion, an average of 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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Invisalign patients from selected pool of investigators
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dr. Thomas Marcel | Livermore | California | 94550 | United States | ||
| Dr. Mary Cooke |
| Type | Date | Date Unknown |
|---|---|---|
| Release | Nov 12, 2020 | |
| Reset | Dec 7, 2020 | |
| Release | Aug 10, 2021 |
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| Napa |
| California |
| 94558 |
| United States |
| Dr. Bella Shen Garnett | San Francisco | California | 94118 | United States |
| Align Technology, Inc. | San Jose | California | 95131 | United States |
| Dr. Robery Van den Berg | San Ramon | California | 94583 | United States |
| Dr. Anil Idiculla | Lone Tree | Colorado | 80124 | United States |
| Dr. Ryan Caudill | Merritt Island | Florida | 32953 | United States |
| Dr. Sean Holliday | Pearl City | Hawaii | 96782 | United States |
| Dr. Jeff Mastroianni | Glen Carbon | Illinois | 62034 | United States |
| Dr. Mark Perelmuter | Louisville | Kentucky | 40207 | United States |
| Dr. James Crouse | Salisbury | Maryland | 21801 | United States |
| Dr. Zvi Kennet | Macomb | Michigan | 48044 | United States |
| Dr. Thomas Everett | Burnsville | Minnesota | 55306 | United States |
| Dr. Justin Wild | Eden Prairie | Minnesota | 55344 | United States |
| Dr. Regina Blevins | Inver Grove Heights | Minnesota | 55076 | United States |
| Dr. William Kottemann | Maple Grove | Minnesota | 55369 | United States |
| Dr. Vincent D'Ascoli | Carson City | Nevada | 89701 | United States |
| Dr. David Chenin | Henderson | Nevada | 89052 | United States |
| Dr. Carlyn Phucas | Marlton | New Jersey | 08053 | United States |
| Dr. David Paquette | Mooresville | North Carolina | 28117 | United States |
| Dr. William Gierie | Wilmington | North Carolina | 28405 | United States |
| Dr. Brian Amy | Oklahoma City | Oklahoma | 73120 | United States |
| Dr. Clark Colville | Seguin | Texas | 78155 | United States |
| Dr. Bart Iwasiuk | Brampton | Ontario | L6Z-4N5 | Canada |
| Reset | Sep 2, 2021 |
| Release | Dec 14, 2021 |
| Reset | Mar 4, 2022 |
| Release | Jul 8, 2022 |
| Reset | May 15, 2023 |
| Release | May 23, 2023 |
| Reset | May 25, 2023 |
| Release | May 25, 2023 |
| Reset | Feb 7, 2024 |
| Release | Feb 9, 2024 |
| Reset | Jul 26, 2024 |
| Release | Oct 23, 2024 |
| Reset | Dec 6, 2024 |
| Release | Dec 10, 2024 |
| Reset | Jan 23, 2025 |
| Release | Jul 23, 2025 |
| Reset | Aug 7, 2025 |
| Release | Oct 9, 2025 |
| Reset | Nov 3, 2025 |
| Release | Nov 3, 2025 |
| Reset | Nov 14, 2025 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Nov 12, 2020 | Dec 7, 2020 | |||
| Aug 10, 2021 | Sep 2, 2021 | |||
| Dec 14, 2021 | Mar 4, 2022 | |||
| Jul 8, 2022 | May 15, 2023 | |||
| May 23, 2023 | May 25, 2023 | |||
| May 25, 2023 | Feb 7, 2024 | |||
| Feb 9, 2024 | Jul 26, 2024 | |||
| Oct 23, 2024 | Dec 6, 2024 | |||
| Dec 10, 2024 | Jan 23, 2025 | |||
| Jul 23, 2025 | Aug 7, 2025 | |||
| Oct 9, 2025 | Nov 3, 2025 | |||
| Nov 3, 2025 | Nov 14, 2025 |
| ID | Term |
|---|---|
| D008310 | Malocclusion |
| ID | Term |
|---|---|
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D009968 | Orthodontic Appliances, Removable |
| ID | Term |
|---|---|
| D009967 | Orthodontic Appliances |
| D009970 | Orthodontics |
| D003813 | Dentistry |
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