A Trial Comparing Deep Versus Moderate Neuromuscular Block - in Low Pressure Pneumoperitoneum

A Randomized Controlled Trial Comparing Deep Versus Moderate Neuromuscular Block - in Low Pressure Pneumoperitoneum - to Optimize the Surgical Conditions During Laparoscopic Donor Nephrectomy

Live kidney transplantation is first choice for patients with end-stage kidney disease. Therefore, the safety and well-being of kidneys donors are highly important objectives in live kidney donation. Low pressure pneumoperitoneum can decrease postoperative pain and therefore also concomitant use of opioids.

However low pressure pneumoperitoneum can also decrease peri-operative conditions. In this trial the researchers will investigate whether peri-operative conditions during low pressure pneumoperitoneum can be optimized by the use of deep neuromuscular block.

Inclusion Criteria:

• obtained informed consent
• age over 18 years

Exclusion Criteria:

• chronic use of analgesics or psychotropic drugs
• use of non-steroidal anti-inflammatory drugs shorter than 5 days before surgery
• known or suspect allergy to rocuronium or sugammadex
• significant liver or renal dysfunction
• pregnant or breastfeeding