Pharmacokinetics of Ciprofloxacin in Pediatric Patients

Pharmacokinetics of Ciprofloxacin in Pediatric Patients With Emphasis on Renal Excretion

Measuring serum and urine concentrations of ciprofloxacin after IV and oral administration in children aged 3 months - 17 years who are treated for urinary tract infections.

Inclusion Criteria:

• age between 3 months and 17 years of age
• confirmed diagnosis of febrile urinary tract infection (a rectal body temperature of 38.5 °C.in combination with either significant leukocyturia or a positive urine nitrite test in a reliable urine sample.
• indication for treatment or uroprophylaxis with ciprofloxacin at discretion of the treating physician.

Exclusion Criteria:

• pregnancy
• impaired renal function as defined by 2x serum creatinine level for age and sex
• epilepsy
• myasthenia gravis
• long QT-syndrome
• glucose 6 phosphatase deficiency (G6PD)
• allergy to one of the substances of cipro
• concomitant use of corticosteroids
• for the oral group: co medication of antacidic drugs, ferrofumarate, calcium, magnesium or Zinc supplements.