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| Name | Class |
|---|---|
| University College Dublin | OTHER |
| Connolly Hospital Blanchardstown | OTHER |
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Acute consumption of dietary nitrate (as beetroot juice) has been shown to decrease systemic blood pressure in multiple populations including newly diagnosed, untreated hypertensives. The additional effect in hypertensives on blood pressure lowering medications is uncertain.
Acute consumption of dietary nitrate (as beetroot juice) has been shown to decrease systemic blood pressure in multiple populations including newly diagnosed, untreated hypertensives. The additional effect in hypertensives on blood pressure lowering medications is uncertain.
The investigators hypothesize that chronic nitrate consumption might decrease blood pressure in hypertensives who are suboptimally controlled on at least one blood pressure medication compared to a placebo beetroot juice.
This study is a randomized, double-blind placebo-controlled, crossover trial. At baseline, mid-point and endpoint ambulatory blood pressure will be assessed in conjunction with demographics and blood draw. After baseline measures, each subject will be randomized to consume nitrate rich beetroot juice for 7 consecutive days when assessments will be repeated followed by 7 days of placebo and endpoint assessments or the converse.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Nitrate rich beetroot juice | Experimental | Concentrated, beetroot juice is a rich source of dietary nitrate. |
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| Nitrate depleted placebo beetroot juice | Placebo Comparator | Placebo beetroot juice is identical to active beetroot juice in every way except nitrate content. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dietary nitrate | Dietary Supplement | 140ml of nitrate rich beetroot juice provides 12.9mmol nitrate and will be consumed on a daily basis during the intervention by the study subjects. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in day ambulatory blood pressure | Day 1, day 15, day 29 |
| Measure | Description | Time Frame |
|---|---|---|
| Change in plasma nitrate | Day 1, day 15, day 29 | |
| Change in 24h ambulatory blood pressure | Day 1, day 15, day 29 | |
| Change in night ambulatory blood pressure |
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Inclusion Criteria:
Exclusion Criteria:
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| Placebo | Dietary Supplement | 140ml of nitrate depleted beetroot juice provides 0.5mmol nitrate and will be consumed on a daily basis during the intervention by the study subjects. |
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| Day 1, day 15, day 29 |
| Change in cardiac biomarkers | Assessed by serum lipids. | Day 1, day 15, day 29 |
| Change in plasma nitrite | Day 1, day 15, day 29 |
| Change in inflammatory biomarkers. | Assessed by serum C-reactive protein. | Day 1, day 15, day 29 |