Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| McMaster University | OTHER |
| Institute for Clinical Evaluative Sciences | OTHER |
The central hypothesis is that surgery and anesthesia exposure in children with immature structural and functional brain development has long-term adverse effects on child development at school-entry compared with children not exposed to anesthesia.
The secondary hypothesis is that frequency of surgery and anesthesia exposure in children with immature structural and functional brain development has a dose-dependent association with worsened child development outcomes at school-entry.
The overall objective is to investigate the association between surgery/anesthesia exposure(s) in children in Ontario and major child development outcomes (physical health and well being, social competence, emotional maturity, and language and cognitive development) at school entry as measured by the Early Development Instrument.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exposed | Exposure to surgery prior to completion of Early Development Instrument |
| |
| Reference | No exposure to surgery prior to completion of Early Development Instrument |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Surgery in early childhood | Other | Surgical interventions in early childhood (prior to completion of Early Development Instrument) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Early developmental vulnerability | Any major domain of the Early Development Instrument in the lowest 10th percentile | Assessed between five and six years of age |
| Measure | Description | Time Frame |
|---|---|---|
| Performance in specific Early Development Instrument domains | Vulnerability (percentage in lowest 10th centile); mean score | Assessed between five and six years of age |
| Multiple challenge index |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Children attending public or Catholic school in Ontario who have completed the Early Development Instrument
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Hospital for Sick Children | Toronto | Ontario | M5G1X8 | Canada |
Not provided
| ID | Term |
|---|---|
| D013514 | Surgical Procedures, Operative |
| D000758 | Anesthesia |
| ID | Term |
|---|---|
| D000760 | Anesthesia and Analgesia |
Not provided
Not provided
Not provided
Not provided
Not provided
Vulnerability (percentage in lowest 10th centile) in ≥9 sub-domains of the Early Development Instrument
| Assessed between five and six years of age |