A Study of LY3200327 in Healthy Participants

A Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LY3200327 in Healthy Subjects

The purpose of this study is to look at the safety and tolerability of single doses of LY3200327 when given to healthy male and female participants either by injection under the skin or by drip into a vein. The study will help determine how the drug behaves inside the body and how long it takes to disappear from the body. The study will also look for anti-drug antibodies and how these may affect how LY3200327 acts in your body.

The study is expected to last approximately 12 weeks (with screening evaluations up to 4 weeks prior).

Inclusion Criteria:

• At the time of initial screening, in general good health
• First-generation healthy Japanese (age 20 to 65 years) will be included

Exclusion Criteria:

• Pregnancy or breastfeeding during the study
• Chronic infection
• Treatment with prohibited medications