HE4 as a Relapse Biomarker in Ovarian Cancers

Determination of the Interest of HE4 as a Relapse Biomarker in Ovarian Cancers Stages IIIb, IIIc and IV After Neo-adjuvant Chemotherapy and Surgery.

HE4 is a more sensitive marker than CA-125 in patients with ovarian cancers. The interest of serum HE4 before surgery has been demonstrated to predict overall survival and its interest has also been shown in combination with CA-125 (ROMA algorithm) to identify high risk patients. To date, no study shows clearly the predictive potential of serum HE4 as an early relapse biomarker in ovarian cancers.

Inclusion Criteria:

• Ovarian adenocarcinoma stage IIIa, IIIb or IV pleural, cytologically or histologically proven
• Patient scheduled to undergo neoadjuvant chemotherapy based on platinum followed by surgery and adjuvant chemotherapy
• Age ≥ 18 years .
• Performance status ECOG > or = 2
• Adequate haemoglobin rate ≥ 10 g/dL
• Ability to provide written informed consent
• Patient's legal capacity to consent to study participation

Exclusion Criteria:

• Any previous treatment with platinum for ovarian carcinoma
• Patient with visceral metastases
• Contraindication for blood test
• Contraindication for surgery
• Contraindication for bevacizumab treatment