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Severe obesity (SO), defined as BMI≥95th percentile, has increased worldwide among adolescents. American studies estimated that 1.3-2.8% of 12-19-year-old individuals have a BMI >40 kg/m2 or a BMI >35 kg/m2 with at least one serious co-morbidity. The immediate and long-term risks associated with SO in adolescents include cardiovascular and metabolic diseases, obstructive sleep apnoea and nonalcoholic fatty liver disease. However, the results of sleeve gastrectomy in adolescents are still uncertain.
Objective and hypotheses: Investigators aimed to assess the long-term safety, efficacy, and cardiovascular risk changes of laparoscopic sleeve gastrectomy in adolescents with SO.
Method: Longitudinal retrospective study of 22 adolescents with SO who underwent laparoscopic sleeve gastrectomy. Clinical and metabolic variables immediately before surgery and after 6, 12, 18 and 24 months were assessed.
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| Measure | Description | Time Frame |
|---|---|---|
| Percent of loss of excess weight following laparoscopic sleeve gastrectomy in severely obese adolescents | weight | up to 24 months |
| percent of reduction in body mass index following laparoscopic sleeve gastrectomy in severely obese adolescents | weight and stature | up to 24 months |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in insulin resistance following laparoscopic sleeve gastrectomy in severely obese adolescents | laboratory assessment- fasting insulinemia | up to 24 months |
| Changes in total cholesterol and and fractions following laparoscopic sleeve gastrectomy in severely obese adolescents |
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Inclusion Criteria:
Exclusion Criteria:
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Severe obese adolescents who underwent laparoscopic sleeve gastrectomy
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| HCFUMSP | São Paulo | São Paulo | 0543-010 | Brazil |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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laboratory assessment- |
| up to 24 months |
| Changes in glucose and and fractions following laparoscopic sleeve gastrectomy in severely obese adolescents | oral glucose tolerance test | up to 24 months |
| Changes in transaminases following laparoscopic sleeve gastrectomy in severely obese adolescents | laboratory assessment- | up to 24 months |
| Changes in uric acid following laparoscopic sleeve gastrectomy in severely obese adolescents | laboratory assessment- | up to 24 months |
| Changes in triglycerides following laparoscopic sleeve gastrectomy in severely obese adolescents | laboratory assessment- | up to 24 months |
| Changes in abdominal ultrasonography ( steatosis )following laparoscopic sleeve gastrectomy in severely obese adolescents | abdominal ultrasonography | up to 24 months |
| Changes in echocardiogram ( concentric hypertrophy of left ventricle )following laparoscopic sleeve gastrectomy in severely obese adolescents | echocardiogram | up to 24 months |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |