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The aim of the study is to assess the peripheral endothelial function in adult COPD (chronic obstructive pulmonary disease) patients and the relationship between the peripheral endothelial function and the pulmonary function.
The primary criteria is the peripheral endothelial function that will be assessed by the measure of flow-mediated dilation (reactive hyperemia-peripheral artery tone index). The pulmonary function will be assessed by the measures of the FEV1 (forced expiratory volume in one second), the forced vital capacity (FVC) and the expiratory flow between 25% and 75% (FEF25-75%). The relationship between these parameters of the pulmonary function and the peripheral endothelial function will be analyzed. In addition, a relationship between peripheral endothelial function and the severity of COPD (classification according to GOLD (Global Initiative for Chronic Obstructive Lung Disease) 2010 and GOLD 2011 and the COPD assessment test, the cardiovascular risk factors (SCORE INdex) and the smoker status will be also assessed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| COPD patients | Experimental | measure of endothelial function with EndoPAT® in COPD patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| COPD patients | Device | measure of peripheral endothelial function by the reactive hyperemia-peripheral artery tone index with a specific device (EndoPAT®) |
|
| Measure | Description | Time Frame |
|---|---|---|
| measure of reactive hyperemia-peripheral artery tone index | measure of reactive hyperemia-peripheral artery tone index | Day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| measure of Forced expiratory flow in one second | measure of Forced expiratory flow in one second | day 1 |
| measure of forced vital capacity | measure of forced vital capacity |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Saint-Antoine | Paris | 75012 | France | |||
| Hôpital Foch |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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| day 1 |
| measure of expiratory flow between 25% and 75% (FEF25-75%). | measure of expiratory flow between 25% and 75% (FEF25-75%). | day 1 |
| Suresnes |
| 92150 |
| France |
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| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |