Cocktail Injection Improves Outcomes of FFR Guided PCI

Intracoronary Cocktail Injection Improves Outcomes of Fractional Flow Reserve Guided Percutaneous Coronary Intervention in Patients With Acute Coronary Syndrom (ACS)

This is a randomized, single blind, controlled study of intracoronary cocktail injection before fractional flow reserve (FFR) measurement when guiding percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS).

This is a randomized, single blind, controlled study of intracoronary cocktail injection before fractional flow reserve (FFR) measurement when guiding percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS). Patients with ACS will be randomized into the cocktail plus FFR guided group or the QCA guided group. The primary outcome of the cocktail II study is the composite of death, myocardial infarction, class IV heart failure and target vessel revascularization within 1 year. The secondary outcome of the cocktail II study include left ventricular function, quality of life, stroke or life-threatening bleeding within 1 year.

Inclusion Criteria:

• patients with a clinical diagnosis of recent ACS within 5 days

Exclusion Criteria:

• haemodynamic instability
• intolerance to anti-platelet drugs
• ineligible for coronary revascularization
• a treatment plan for non-coronary heart surgery (e.g. valve surgery)
• a history of prior PCI or CABG
• angiographic evidence of severe (e.g. diffuse calcification) or mild (<30% severity) coronary disease
• a life expectancy less than 1 year
• adenosine allergy