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Animal studies have shown that the level of pain sensitivity is highly dependent on the amount of polyamines in food. This fundamental observation of a nutritional approach to pain led the authors to develop diets completely depleted in polyamines whose anti-nociceptive properties have been confirmed in animals.
Postoperative pain after foot surgery are currently fairly well controlled but at the cost of a high consumption of grade II analgesics which is associated with a high rate of side effects (nausea, vomiting ...). The investigators' hypothesis is that a diet low in polyamines may have an additive effect on pain control and reduce the consumption of level 2 analgesics.
The objective of this study is to show the efficacy of a polyamines-poor diet on postoperative pain in ambulatory surgery of the foot.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| poor-polyamines diet | Experimental |
| |
| high-polyamines diet | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| poor-polyamines diet | Other | Patients in this will receive a poor-polyamines diet during a week before and a week after foot surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of patients whose worst pain, as measured on an visual analogic scale ranging from 0 mm to 100 mm, was at least once rated as 30 mm or more. | The worst pain will be assessed retrospectively the eighth day after surgery | Eight days after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of patients with a need for grade II analgesics | Eighth day after surgery | |
| Overall tramadol consumption , expressed in mg. | Eight days after surgery | |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Groupe hospitalier Diaconesses Croix Saint Simon | Paris | Île-de-France Region | 75020 | France |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| high polyamines diet | Other | Patients in this will receive a high-polyamines diet during a week before and a week after foot surgery |
|
| Worst pain, expressed in mm, measured on an visual analogic scale ranging from 0 mm to 100 mm |
The worst pain will be assessed retrospectively the eighth day after surgery |
| Eight days after surgery |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |