Cognitive Behavioral Intervention for Targeted Therapy Fatigue (CBT-TTF) Intervention

Preliminary Evaluation of an Internet-Assisted Cognitive Behavioral Intervention for Targeted Therapy Fatigue

The purpose of this study is to evaluate Cognitive Behavioral Intervention for Targeted Therapy Fatigue (CBT-TTF) with fatigued chronic myelogenous leukemia (CML) patients on tyrosine kinase inhibitors (TKIs) for feasibility, acceptability and potential efficacy relative to usual care only in a small-scale randomized controlled trial.

Inclusion Criteria:

• able to speak/read English
• diagnosed with chronic phase CML
• not have been treated for other cancer (except non-melanoma skin cancer) in the past 5 years
• be under the care of a Moffitt Cancer Center (MCC) physician
• be on a stable dose of the same oral TKI for >= 3 months
• new onset or worsening of fatigue since starting TKI
• report moderate-severe fatigue in past week (FSI average rating >= 4 of 0-10)
• have no clinical history of disease (e.g., multiple sclerosis, fibromyalgia) that could account for their fatigue presentation

Exclusion Criteria:

• scheduled to discontinue their TKI under medical supervision within the next 3 months