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The purpose of this study is to investigate the metabolic and endocrine responses during 3 hour after taking 75g fructose or glucose in young Chinese.
The study was a double-blinded, randomized, crossover trial. Twenty healthy volunteers were randomized to two groups: group A (300ml of 22.5% glucose) and group B (300ml of 22.5% fructose).Volunteer was randomized into either group A or B, after an 8-h overnight fasting, took 300ml of solution at 0830 within 5 minutes. After one-week washout period, volunteer was crossed over for either group B or A. each intervention, venous blood was collected at 0h, 0.5h, 1h, 2h, and 3h and blood pressure was tested at 0h, 1h, 2h, and 3h.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group fructose | Experimental | Volunteer was randomized into either group fructose or glucose |
|
| group glucose | Experimental | After one-week washout period, volunteer was crossed over for either group glucose or fructose. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| fructose | Dietary Supplement | 75g fructose is dissolved in 300 ml water.After overnight fasting, 300ml of solution at 0830 within 5 minutes is taken by volunteers |
|
| Measure | Description | Time Frame |
|---|---|---|
| serum uric acid | Serum uric acid concentration was analyzed on HITACHI 7020 chemistry analyzer using enzyme-based colorimetric test or colorimetric test supplied by DiaSys Diagnostic Systems (Shanghai) Co., Ltd | 3 hours |
| Measure | Description | Time Frame |
|---|---|---|
| blood pressure | Blood pressure was measured at Zhejiang University Hospital by the research workers who were blind to the groups within 3 hours blood collection. | 3 hours |
| Measure | Description | Time Frame |
|---|---|---|
| serum glucose | Serum glucose level was analyzed on HITACHI 7020 chemistry analyzer using enzyme-based colorimetric test or colorimetric test supplied by Diasys Diagnostic Systems (Shanghai) Co., Ltd | 3 hours |
| nitric oxide |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Duo Li, Doctor | College of Biosystem Engineering & Food Science, Zhejiang University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zhejiang university | Hangzhou | Zhejiang | 310000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19064535 | Background | Fulgoni V 3rd. High-fructose corn syrup: everything you wanted to know, but were afraid to ask. Am J Clin Nutr. 2008 Dec;88(6):1715S. doi: 10.3945/ajcn.2008.25825A. | |
| 22152650 | Background | Le MT, Frye RF, Rivard CJ, Cheng J, McFann KK, Segal MS, Johnson RJ, Johnson JA. Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects. Metabolism. 2012 May;61(5):641-51. doi: 10.1016/j.metabol.2011.09.013. Epub 2011 Dec 5. |
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| ID | Term |
|---|---|
| D005632 | Fructose |
| D005947 | Glucose |
| ID | Term |
|---|---|
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D000073893 | Sugars |
| D002241 | Carbohydrates |
| D007661 |
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| glucose | Dietary Supplement | 75g glucose is dissolved in 300 ml water.After overnight fasting, 300ml of solution at 0830 within 5 minutes is taken by volunteers |
|
Serum nitric oxide concentration was measured using NO assay kit (Nanjing Jiancheng Technology Co., Lte., Nanjing, China) by the research workers who were blind to the groups.
| 3 hours |
| aldose reductase | Enzymatic activity of aldose reductase in serum was measured using ELISA kit (Shanghai Changjin Biology Co., Lte., Shanghai, China ) by the research workers who were blind to the groups. | 3 hours |
| phosphofructokinase | Enzymatic activity of phosphofructokinase in serum was measured using ELISA kit (Shanghai Changjin Biology Co., Lte., Shanghai, China ) by the research workers who were blind to the groups . | 3 hours |
| insulin | Serum insulin concentration was analyzed on HITACHI 7020 chemistry analyzer using enzyme-based colorimetric test or colorimetric test supplied by Diasys Diagnostic Systems (Shanghai) Co., Ltd | 3 hours |
| insulin-c | Serum insulin-c concentration was analyzed on HITACHI 7020 chemistry analyzer using enzyme-based colorimetric test or colorimetric test supplied by Diasys Diagnostic Systems (Shanghai) Co., Ltd | 3 hours |
| triglyceride | Triglyceride concentration in serum was analyzed on HITACHI 7020 chemistry analyzer using enzyme-based colorimetric test or colorimetric test supplied by Diasys Diagnostic Systems (Shanghai) Co., Ltd | 3 hours |
| total cholesterol | Total cholesterol concentration was analyzed on HITACHI 7020 chemistry analyzer using enzyme-based colorimetric test or colorimetric test supplied by Diasys Diagnostic Systems (Shanghai) Co., Ltd | 3 hours |
| high-density cholesterol | High-density cholesterol was analyzed on HITACHI 7020 chemistry analyzer using enzyme-based colorimetric test or colorimetric test supplied by Diasys Diagnostic Systems (Shanghai) Co., Ltd. | 3 hours |
| low-density cholesterol | Low-density cholesterol concentration was analyzed on HITACHI 7020 chemistry analyzer using enzyme-based colorimetric test or colorimetric test supplied by Diasys Diagnostic Systems (Shanghai) Co., Ltd. | 3 hours |
| lactate dehydrogenase | Enzymatic activity of lactate dehydrogenase was analyzed on HITACHI 7020 chemistry analyzer using enzyme-based colorimetric test or colorimetric test supplied by Diasys Diagnostic Systems (Shanghai) Co., Ltd. | 3 hours |
| Ketoses |